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GRB2-1:SOS1 binds p-IRS1,p-IRS2
An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-74736)
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Statements
instance of
biological process
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-74736
part of
SOS-mediated signalling
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-74736
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-74736
exact match
https://identifiers.org/reactome:R-HSA-74736
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-74736
has part(s)
GRB2-1:SOS1 [cytosol]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-74736
p-Y-IRS1,p-Y-IRS2 [cytosol]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-74736
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol]
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-74736
cites work
The function of GRB2 in linking the insulin receptor to Ras signaling pathways
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-74736
Systematic mapping of potential binding sites for Shc and Grb2 SH2 domains on insulin receptor substrate-1 and the receptors for insulin, epidermal growth factor, platelet-derived growth factor, and fibroblast growth factor
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-74736
Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-74736
Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-74736
Substrate specificities of the insulin and insulin-like growth factor 1 receptor tyrosine kinase catalytic domains
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-74736
Differential regulation of insulin receptor substrate-2 and mitogen-activated protein kinase tyrosine phosphorylation by phosphatidylinositol 3-kinase inhibitors in SH-SY5Y human neuroblastoma cells.
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-74736
Roles of insulin receptor substrate-1 and Shc on insulin-like growth factor I receptor signaling in early passages of cultured human fibroblasts.
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-74736
Identifiers
Reactome ID
R-HSA-74736
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-74736
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