(Q100152544)

English

KIT mutants bind GRB2-SOS

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-9670428)

In more languages

default for all languages

No label defined

No description defined

edit

Statements

1 reference

8 July 2022

Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-9670428

1 reference

8 July 2022

GRB2-1:SOS1 [cytosol]

quantity

1

object of statement has role

1 reference

8 July 2022

p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane]

quantity

1

object of statement has role

1 reference

8 July 2022

p-KIT mutants:GRB2:SOS [plasma membrane]

quantity

1

object of statement has role

1 reference

8 July 2022

Juxtamembrane mutant V560GKit is more sensitive to Imatinib (STI571) compared with wild-type c-kit whereas the kinase domain mutant D816VKit is resistant.

1 reference

8 July 2022

c-Kit mutants require hypoxia-inducible factor 1alpha to transform melanocytes

1 reference

8 July 2022

Oncogenic signaling by Kit tyrosine kinase occurs selectively on the Golgi apparatus in gastrointestinal stromal tumors

1 reference

8 July 2022

ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours

1 reference

8 July 2022

Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumor growth

1 reference

8 July 2022

KRAS and KIT Gatekeeper Mutations Confer Polyclonal Primary Imatinib Resistance in GI Stromal Tumors: Relevance of Concomitant Phosphatidylinositol 3-Kinase/AKT Dysregulation

1 reference

8 July 2022

KIT oncoprotein interactions in gastrointestinal stromal tumors: therapeutic relevance

1 reference

8 July 2022

Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells

1 reference

8 July 2022

Stem cell factor receptor/c-Kit: from basic science to clinical implications

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q100152544)

KIT mutants bind GRB2-SOS

Statements

Identifiers

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)