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Activated FGFR2:pFRS binds GRB2:SOS1
An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-5654615)
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Statements
instance of
biological process
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5654615
part of
FRS-mediated FGFR2 signaling
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5654615
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5654615
exact match
https://identifiers.org/reactome:R-HSA-5654615
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5654615
has part(s)
Activated FGFR2:p-FRS [plasma membrane]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5654615
GRB2-1:SOS1 [cytosol]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5654615
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane]
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5654615
cites work
A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5654615
Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5654615
Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5654615
Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5654615
Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5654615
Identifiers
Reactome ID
R-HSA-5654615
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5654615
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