(Q100156088)

English

Active FLT3 binds PTPN11

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-9604969)

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Statements

biological process

1 reference

8 July 2022

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-9604969

1 reference

8 July 2022

Active FLT3 [plasma membrane]

1

object has role

1 reference

8 July 2022

Protein tyrosine phosphatase non-receptor type 11

1

object has role

1 reference

8 July 2022

Active FLT3:PTPN11 [plasma membrane]

1

object has role

1 reference

8 July 2022

Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2

1 reference

8 July 2022

The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo

1 reference

8 July 2022

Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways.

1 reference

8 July 2022

Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD.

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

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