(Q100235374)

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FLT3 Signaling

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9607240)

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8 July 2022

cytokine-mediated signaling pathway

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Cytokine Signaling in Immune system

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https://identifiers.org/reactome:R-HSA-9607240

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FLT3LG dimer binds FLT3

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FLT3LG dimer:FLT3 binds FLT3

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FLT3LG dimer:FLT3 dimer autophosphorylates

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Active FLT3 dimer binds GRB2

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Active FLT3:GRB2 binds SOS1

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SOS1-mediated nucleotide exchange of RAS downstream of FLT3

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Active FLT3:GRB2 binds GAB2

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GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated

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Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1

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Active FLT3:GRB2:p-Y-GAB2 binds PTPN11

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Active FLT3 binds PTPN11

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FLT3 signaling through SRC family kinases

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Active FLT3 binds to GRAP2

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Active FLT3 binds to GRB10

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FLT3 phosphorylates GRB10

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Active FLT3:p-Y-GRB10 binds PIK3R1

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Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA

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Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA

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AKT phosphorylates FOXO3 downstream of FLT3

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AKT-phosphorylated FOXO3 translocates to cytosol

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FOXO3-dependent BCL2L11 gene expression

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FOXO3-dependent CDKN1B gene expression

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Active FLT3 phosphorylates CDKN1B

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FLT3 binds type I TKI

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FLT3 binds type II TKI

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Negative regulation of FLT3

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An overview on the role of FLT3-tyrosine kinase receptor in acute myeloid leukemia: biology and treatment

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8 July 2022

Identifiers

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8 July 2022

(Q100235374)

FLT3 Signaling

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