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Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-9698170)
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Statements
instance of
biological process
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9698170
part of
FLT3 Signaling
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9698170
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9698170
exact match
https://identifiers.org/reactome:R-HSA-9698170
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9698170
has part(s)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9698170
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9698170
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane]
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9698170
cites work
Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9698170
p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9698170
A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9698170
Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9698170
A frequent kinase domain mutation that changes the interaction between PI3K and the membrane
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9698170
FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9698170
Identifiers
Reactome ID
R-HSA-9698170
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9698170
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