(Q104713115)

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FLT3 signaling through SRC family kinases

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9706374)

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8 July 2022

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-9706374

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8 July 2022

Active FLT3 binds FYN

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8 July 2022

Active FLT3 binds HCK

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8 July 2022

Active FLT3 binds to LCK

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8 July 2022

Active FLT3 binds to SYK

1 reference

8 July 2022

Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2

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8 July 2022

Src family tyrosine kinases phosphorylate Flt3 on juxtamembrane tyrosines and interfere with receptor maturation in a kinase-dependent manner

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8 July 2022

FYN expression potentiates FLT3-ITD induced STAT5 signaling in acute myeloid leukemia.

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8 July 2022

Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells

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8 July 2022

The Src family kinase LCK cooperates with oncogenic FLT3/ITD in cellular transformation

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8 July 2022

SYK is a critical regulator of FLT3 in acute myeloid leukemia

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8 July 2022

FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

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8 July 2022

The role of SRC family kinases in FLT3 signaling

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q104713115)

FLT3 signaling through SRC family kinases

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