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Active FLT3 phosphorylates CDKN1B
An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-9699578)
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Statements
instance of
biological process
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9699578
part of
FLT3 Signaling
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9699578
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9699578
exact match
https://identifiers.org/reactome:R-HSA-9699578
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9699578
has part(s)
ATP(4-)
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9699578
Cyclin dependent kinase inhibitor 1B
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9699578
ADP(3-)
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9699578
p-Y88-CDKN1B [cytosol]
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9699578
Active FLT3 [plasma membrane]
quantity
1
object has role
modifier
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9699578
cites work
FLT3 and FLT3-ITD phosphorylate and inactivate the cyclin-dependent kinase inhibitor p27Kip1 in acute myeloid leukemia
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9699578
Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9699578
p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes.
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9699578
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9699578
Identifiers
Reactome ID
R-HSA-9699578
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9699578
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