(Q100241838)

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NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9029569)

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8 July 2022

NR1H2 and NR1H3-mediated signaling

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-9029569

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8 July 2022

Oxysterol-induced binding of NR1H2,3:RXR to the ABCG1 gene

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8 July 2022

Expression of ABCG1 regulated by NR1H2,3

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Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex

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Co-repressor complex dissociates from the transcription unit of the ABCA1 gene

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NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex

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NCOA1 recruits EP300 to the ABCA1 promoter

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ABCA1 gene transcription regulated by NR1H2 or NR1H3

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miR-26 binds to the 3'UTR of the ABCA1 mRNA

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miR-33 binds to the 3'UTR of the ABCA1 mRNA

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miR-144 binds to the 3'UTR of the ABCA1 mRNA

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ABCA1 mRNA is translated

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NR1H2,3 binds the ABCG5 gene

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Expression of ABCG5 regulated by NR1H2,3

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NR1H2,3 binds the ABCG8 gene

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8 July 2022

Expression of ABCG8 regulated by NR1H2 or NR1H3

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NR1H2,3 binds the CETP gene

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Expression of CETP regulated by NR1H2 or NR1H3

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8 July 2022

NR1H2,3 binds the PLTP gene

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Expression of PLTP regulated by NR1H2 or NR1H3

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8 July 2022

NR1H2,3 binds the APOE gene

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Expression of APOE regulated by NR1H2 or NR1H3

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NR1H2,3 binds the APOC1 gene

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Expression of APOC1 regulated by NR1H2 or NR1H3

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NR1H2,3 binds the APOC2 gene

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8 July 2022

Expression of APOC2 regulated by NR1H2 or NR1H3

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NR1H2,3 binds the APOC4 gene

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Expression of APOC4 regulated by NR1H2 or NR1H3

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NR1H2,3 binds the APOD gene

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Expression of APOD regulated by NR1H2 or NR1H3

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NR1H2,3 binds the EEPD1 gene

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8 July 2022

Expression of EEPD1 regulated by NR1H2 or NR1H3

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8 July 2022

NR1H2,3 binds the NR1H3 gene

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NR1H3 gene transcription regulated by NR1H2,3

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8 July 2022

miR-613 binds to the 3'UTR of the NR1H3 mRNA

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8 July 2022

NR1H3 mRNA is translated

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8 July 2022

NR1H2,3 binds the ARL4C gene

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ARL4C gene transcription regulated by NR1H2,3

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8 July 2022

ARL4C mRNA is translated

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8 July 2022

miR-26 binds to the 3'UTR of the ARL4C mRNA

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8 July 2022

Liver X Receptors and their Agonists: Targeting for Cholesterol Homeostasis and Cardiovascular Diseases

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8 July 2022

Liver X receptor in cholesterol metabolism

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8 July 2022

Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q100241838)

NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux

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