(Q104910667)

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Insertional Inactivation of Methylmalonyl Coenzyme A (CoA) Mutase and Isobutyryl-CoA Mutase Genes in Streptomyces cinnamonensis: Influence on Polyketide Antibiotic Biosynthesis

scientific article published on 31 December 2019

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Insertional Inactivation of Methylmalonyl Coenzyme A (CoA) Mutase and Isobutyryl-CoA Mutase Genes in Streptomyces cinnamonensis: Influence on Polyketide Antibiotic Biosynthesis (English)

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http://api.crossref.org/works/10.1128%2Fjb.181.18.5600-5605.1999

Streptomyces cinnamonensis

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Streptomyces glaucescens

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S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] butanethioate

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monensin (unspec.)

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methylmalonyl-CoA

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isobutyryl-coenzyme A

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author name string

Jan W. Vrijbloed

1

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http://api.crossref.org/works/10.1128%2Fjb.181.18.5600-5605.1999

Katja Zerbe-Burkhardt

2

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http://api.crossref.org/works/10.1128%2Fjb.181.18.5600-5605.1999

Ananda Ratnatilleke

3

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http://api.crossref.org/works/10.1128%2Fjb.181.18.5600-5605.1999

Andreas Grubelnik-Leiser

4

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John A. Robinson

5

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publication date

31 December 2019

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full work available at URL

https://jb.asm.org/content/jb/181/18/5600.full.pdf

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Journal of Bacteriology

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181

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18

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5600-5605

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online access status

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Milbemycins, a new family of macrolide antibiotics. Studies on the biosynthesis of milbemycins alpha 2, alpha 4 and D using 13C labeled precursors.

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Biosynthesis of monensins A and B

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Purification of crotonyl-CoA reductase from Streptomyces collinus and cloning, sequencing and expression of the corresponding gene in Escherichia coli.

1 reference

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Cloning and sequencing of the coenzyme B(12)-binding domain of isobutyryl-CoA mutase from Streptomyces cinnamonensis, reconstitution of mutase activity, and characterization of the recombinant enzyme produced in Escherichia coli

1 reference

12 April 2024

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A protein having similarity with methylmalonyl-CoA mutase is required for the assimilation of methanol and ethanol by Methylobacterium extorquens AM1.

1 reference

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Manipulation of Modular Polyketide Synthases.

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Genetic Contributions to Understanding Polyketide Synthases

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Molecular analysis of the anaerobic succinate degradation pathway in Clostridium kluyveri

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Characterization of a unique methyl-specific restriction system in Streptomyces avermitilis

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Biosynthesis of monensin

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Biosynthesis of lasalocid A. Metabolic interrelationships of carboxylic acid precursors and polyether antibiotics

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Biosynthesis of the polyether antibiotic monensin-A. Results from the incorporations of labelled acetate and propionate as a probe of the carbon chain assembly processes

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Biosynthesis of the polyether antibiotic ICI139603 in Streptomyces longisporoflavus: investigation of deuterium retention after incorporation of CD3 13CO2H, 13CD3CO2H, and CH3CD2 13CO2H using 2H n.m.r. and edited 13C n.m.r. spectra

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Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis

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Cloning and characterization of a gene (msdA) encoding methylmalonic acid semialdehyde dehydrogenase from Streptomyces coelicolor

1 reference

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Combinatorial approaches to polyketide biosynthesis

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The genetic basis of precursor supply for the biosynthesis of macrolide and polyether antibiotics

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Biosynthesis of nonactin. The role of acetoacetyl-CoA in the formation nonactic acid

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Cloning, sequencing, and expression of the gene encoding methylmalonyl-coenzyme A mutase from Streptomyces cinnamonensis

1 reference

12 April 2024

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Occurrence, metabolism, metabolic role, and industrial uses of bacterial polyhydroxyalkanoates

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The use of 13C-NMR. Spectroscopy in biosynthetic studies. II[1]. Biosynthesis of narasin, a new polyether ionophore from fermentation of Streptomyces aureofaciens [2]

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Cloning, Sequencing, Expression, and Insertional Inactivation of the Gene for the Large Subunit of the Coenzyme B12-dependent Isobutyryl-CoA Mutase from Streptomyces cinnamonensis

1 reference

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Purification and properties of an iron-sulfur and FAD-containing 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA delta 3-delta 2-isomerase from Clostridium aminobutyricum

1 reference

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Branched-chain amino acid catabolism in bacteria

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Metabolic pathway for poly(3-hydroxybutyrate-co-3-hydroxyvalerate) formation in Nocardia corallina: inactivation of mutB by chromosomal integration of a kanamycin resistance gene

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Valine as a precursor of n-butyrate unit in the biosynthesis of macrolide aglycone

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10.1128/JB.181.18.5600-5605.1999

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