(Q105300773)

English

Tetracenomycin M, a Novel Genetically Engineered Tetracenomycin Resulting from a Combination of Mithramycin and Tetracenomycin Biosynthetic Genes

scientific article published on 20 July 2007

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scholarly article

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Tetracenomycin M, a Novel Genetically Engineered Tetracenomycin Resulting from a Combination of Mithramycin and Tetracenomycin Biosynthetic Genes (English)

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http://api.crossref.org/works/10.1002%2Fchem.19970031017

Streptomyces glaucescens

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tetracenomycin M

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author name string

Eva Künzel

1

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http://api.crossref.org/works/10.1002%2Fchem.19970031017

Sven-Eric Wohlert

2

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http://api.crossref.org/works/10.1002%2Fchem.19970031017

Claus Beninga

3

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http://api.crossref.org/works/10.1002%2Fchem.19970031017

Sabine Haag

4

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http://api.crossref.org/works/10.1002%2Fchem.19970031017

Heinrich Decker

5

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http://api.crossref.org/works/10.1002%2Fchem.19970031017

C. Richard Hutchinson

6

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http://api.crossref.org/works/10.1002%2Fchem.19970031017

Gloria Blanco

7

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http://api.crossref.org/works/10.1002%2Fchem.19970031017

Carmen Mendez

8

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http://api.crossref.org/works/10.1002%2Fchem.19970031017

Jose A. Salas

9

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http://api.crossref.org/works/10.1002%2Fchem.19970031017

Jürgen Rohr

10

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http://api.crossref.org/works/10.1002%2Fchem.19970031017

publication date

October 1997

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16 September 2022

Chemistry—A European Journal

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3

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1675-1678

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Biosynthetic Origin of the Oxygen Atoms of Tetracenomycin C

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Novel Genetically Engineered Tetracenomycins

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Comparison of multicyclic polyketides by folding analysis: a novel approach to recognize biosynthetic and/or evolutionary interrelationships of the natural products or intermediates and its exemplification on hepta-, octa-, and decaketides

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Metabolic products of microorganisms. 249. Tetracenomycins B3 and D3, key intermediates of the elloramycin and tetracenomycin C biosynthesis

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Balmoralmycin, a new angucyclinone, and two related biosynthetic shunt products containing a novel ring system

1 reference

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New anthracycline metabolites from mutant strains of Streptomyces galilaeus MA144-M1. II. Structure of 2-hydroxyaklavinone and new aklavinone glycosides

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Streptomycin-sensitivity in Streptomyces glaucescens is due to deletions comprising the structural gene coding for a specific phosphotransferase

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Combinatorial biosynthesis of 'unnatural' natural products: the polyketide example

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Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin

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Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents

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Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Saccharopolyspora erythraea (Streptomyces erythreus)

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Anthracycline metabolites of tetracenomycin C-nonproducing Streptomyces glaucescens mutants

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A functional chimeric modular polyketide synthase generated via domain replacement

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9 March 2024

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Tetracenomycin F2 cyclase: intramolecular aldol condensation in the biosynthesis of tetracenomycin C in Streptomyces glaucescens

1 reference

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Engineered biosynthesis of novel polyketides: evidence for temporal, but not regiospecific, control of cyclization of an aromatic polyketide precursor.

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Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesis

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Pigments of marine animals. VI. Anthraquinoid pigments of the crinoids Ptilometra australis Wilton and Tropiometra afra Hartlaub

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Generation of polyketide libraries via combinatorial biosynthesis

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Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits

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Tetracenomycin F1 monooxygenase: oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin C in Streptomyces glaucescens

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Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin

1 reference

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Isolation and structural elucidation of tetracenomycin F2 and tetracenomycin F1: early intermediates in the biosynthesis of tetracenomycin C in Streptomyces glaucescens

1 reference

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Engineered biosynthesis of novel polyketides

1 reference

9 March 2024

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A hybrid modular polyketide synthase obtained by domain swapping

1 reference

9 March 2024

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Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin

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Biogenesis of chromomycin A3 by Streptomyces griseus

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Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.

2 references

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https://opencitations.net/index/api/v1/citations/10.1002/J.1460-2075.1989.TB08414.X

Engineered Biosynthesis of Structurally Diverse Tetraketides by a Trimodular Polyketide Synthase

1 reference

9 March 2024

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Identifiers

10.1002/CHEM.19970031017

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