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Mechanism of action of hydroxychloroquine as an antirheumatic drug
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title
Mechanism of action of hydroxychloroquine as an antirheumatic drug
(English)
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author name string
Robert I. Fox
series ordinal
1
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publication date
October 1993
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published in
Seminars in Arthritis and Rheumatism
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volume
23
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issue
2
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page(s)
82-91
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cites work
Differential effects of mepacrine, chloroquine and hydroxychloroquine on superoxide anion generation, phospholipid methylation and arachidonic acid release by human blood monocytes
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A dose-ranging study of the pharmacokinetics of hydroxy-chloroquine following intravenous administration to healthy volunteers
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Lysosomes, pH and the Anti-malarial Action of Chloroquine
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Acid-vesicle function, intracellular pathogens, and the action of chloroquine against Plasmodium falciparum
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A perspective on antimalarial action: effects of weak bases on Plasmodium falciparum
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Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance.
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Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites
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Acidification of the endocytic and exocytic pathways
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Receptor-mediated endocytosis
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Chloroquine and ammonium ion inhibit receptor-mediated endocytosis of mannose-glycoconjugates by macrophages: apparent inhibition of receptor recycling
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Recycling of the asialoglycoprotein receptor and the effect of lysosomotropic amines in hepatoma cells
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Receptor-mediated endocytosis of hormones in cultured cells
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Inhibition of Human Immunodeficiency Virus Infectivity by Chloroquine
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Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment
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Subunit of the '20S' proteasome (multicatalytic proteinase) encoded by the major histocompatibility complex
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Second proteasome-related gene in the human MHC class II region
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Antigen-Presenting Function of the Macrophage
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Class II MHC molecules can use the endogenous pathway of antigen presentation
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Autoimmune diseases: the failure of self tolerance
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Control of granulocytes and macrophages: molecular, cellular, and clinical aspects
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Regulation of antigen presentation by acidic pH.
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How MHC class II molecules work: peptide-dependent completion of protein folding.
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Membrane insertion and oligomeric assembly of HLA-DR histocompatibility antigens
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Intracellular transport of class II MHC molecules directed by invariant chain.
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Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways
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MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding
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Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules
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Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells
1 reference
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Chloroquine affects biosynthesis of Ia molecules by inhibiting dissociation of invariant (gamma) chains from alpha-beta dimers in B cells
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The human class II MHC protein HLA-DR1 assembles as empty alpha beta heterodimers in the absence of antigenic peptide
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Immunosuppressive potential of antimalarials
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Chloroquine treatment in rheumatoid arthritis. Correlation of clinical response to plasma protein changes and chloroquine levels
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10.1016/S0049-0172(10)80012-5
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