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QnAs with Svetlana Mojsov, Joel Habener, and Lotte Bjerre Knudsen: Winners of the 2024 Lasker~DeBakey Clinical Medical Research Award

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QnAs with Svetlana Mojsov, Joel Habener, and Lotte Bjerre Knudsen: Winners of the 2024 Lasker~DeBakey Clinical Medical Research Award (English)

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Prashant Nair

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publication date

19 September 2024

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full work available at URL

http://dx.doi.org/10.1073/pnas.2416868121

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Proceedings of the National Academy of Sciences of the United States of America

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121

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issue

39

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Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International

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cites work

The ‘breakthrough’ obesity drugs that have stunned researchers

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Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem

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Hamster preproglucagon contains the sequence of glucagon and two related peptides

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An improved synthesis of crystalline mammalian glucagon

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The incretin concept today

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Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing

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Both amidated and nonamidated forms of glucagon-like peptide I are synthesized in the rat intestine and the pancreas

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Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas

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Discovery, characterization, and clinical development of the glucagon-like peptides

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The GLP-1 journey: from discovery science to therapeutic impact

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From the Incretin Concept and the Discovery of GLP-1 to Today's Diabetes Therapy

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Insulinotropic action of glucagonlike peptide-I-(7-37) in diabetic and nondiabetic subjects

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Small-molecule agonists for the glucagon-like peptide 1 receptor

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Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration

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A role for glucagon-like peptide-1 in the central regulation of feeding

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Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences

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Liraglutide, a long-acting glucagon-like peptide-1 analog, reduces body weight and food intake in obese candy-fed rats, whereas a dipeptidyl peptidase-IV inhibitor, vildagliptin, does not.

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The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

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The Discovery and Development of Liraglutide and Semaglutide

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Identifiers

DOI

10.1073/PNAS.2416868121

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https://api.crossref.org/v1/works/10.1073/pnas.2416868121

(Q130375905)

QnAs with Svetlana Mojsov, Joel Habener, and Lotte Bjerre Knudsen: Winners of the 2024 Lasker~DeBakey Clinical Medical Research Award

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