(Q14762286)

English

Insulin II

mammalian protein found in Mus musculus

insulin-2
uniprot:P01326
Ins2
proinsulin

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Insulin/IGF/Relaxin family

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01326

Insulin-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01326

Insulin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Insulin, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

insulin-like growth factor receptor binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

insulin receptor binding

determination method

1 reference

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01326&geneProductId=UniProtKB:P01326

determination method

hormone activity

determination method

3 references

identical protein binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

protease binding

determination method

2 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

determination method

1 reference

24 April 2018

Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01326&geneProductId=UniProtKB:P01326

determination method

sno(s)RNA-containing ribonucleoprotein complex

determination method

1 reference

14 February 2019

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

determination method

1 reference

14 February 2019

Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

extracellular region

determination method

3 references

secretory granule lumen

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

determination method

1 reference

14 February 2019

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

secretory granule

determination method

3 references

collagen-containing extracellular matrix

determination method

1 reference

14 February 2019

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

biological process

negative regulation of proteolysis

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

positive regulation of glucose import

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

G protein-coupled receptor signaling pathway

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

myotube differentiation

determination method

1 reference

14 February 2019

Insulin and wnt1 pathways cooperate to induce reserve cell activation in differentiation and myotube hypertrophy

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

activation of protein kinase B activity

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

positive regulation of protein metabolic process

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

positive regulation of glycogen biosynthetic process

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

positive regulation of protein kinase B signaling

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

negative regulation of acute inflammatory response

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

regulation of cellular amino acid metabolic process

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

negative regulation of protein catabolic process

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

negative regulation of protein oligomerization

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

alpha-beta T cell activation

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

regulation of phosphorylation

determination method

1 reference

14 February 2019

Proinsulin C-peptide activates cAMP response element-binding proteins through the p38 mitogen-activated protein kinase pathway in mouse lung capillary endothelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

negative regulation of respiratory burst involved in inflammatory response

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

14 February 2019

Hepatocyte nuclear factor-1 acts as an accessory factor to enhance the inhibitory action of insulin on mouse glucose-6-phosphatase gene transcription

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

negative regulation of glycogen catabolic process

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

negative regulation of NAD(P)H oxidase activity

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

determination method

1 reference

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01326&geneProductId=UniProtKB:P01326

determination method

ER overload response

determination method

1 reference

14 February 2019

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

regulation of protein localization

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

positive regulation of phosphatidylinositol 3-kinase activity

determination method

1 reference

14 February 2019

Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

lipid catabolic process

determination method

1 reference

14 February 2019

Ras-GRF1 signaling is required for normal beta-cell development and glucose homeostasis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

determination method

1 reference

14 February 2019

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

fatty acid homeostasis

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

positive regulation of NF-kappaB transcription factor activity

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

acute-phase response

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

negative regulation of feeding behavior

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

positive regulation of cell population proliferation

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

regulation of transmembrane transporter activity

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

regulation of gene expression

determination method

1 reference

24 April 2018

Regulated renin release from 3T3-L1 adipocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01326&geneProductId=UniProtKB:P01326

determination method

canonical Wnt signaling pathway

determination method

1 reference

14 February 2019

Insulin and wnt1 pathways cooperate to induce reserve cell activation in differentiation and myotube hypertrophy

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

positive regulation of phosphatidylinositol 3-kinase signaling

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

positive regulation of insulin receptor signaling pathway

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

myoblast fusion

determination method

1 reference

14 February 2019

Insulin and wnt1 pathways cooperate to induce reserve cell activation in differentiation and myotube hypertrophy

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

regulation of protein binding

determination method

1 reference

14 February 2019

Identification of sirm, a novel insulin-regulated SH3 binding protein that associates with Grb-2 and FYN

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

negative regulation of lipid catabolic process

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

positive regulation of respiratory burst

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

positive regulation of mitotic nuclear division

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

negative regulation of protein secretion

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

positive regulation of glycolytic process

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

negative regulation of fatty acid metabolic process

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

positive regulation of MAPK cascade

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

positive regulation of protein localization to nucleus

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

regulation of protein secretion

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

positive regulation of gene expression

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

positive regulation of dendritic spine maintenance

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

regulation of protein localization to plasma membrane

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

negative regulation of reactive oxygen species biosynthetic process

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

neuron projection maintenance

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

carbohydrate metabolic process

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

regulation of signaling receptor activity

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

positive regulation of nitric oxide mediated signal transduction

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

glucose transmembrane transport

determination method

1 reference

14 February 2019

Cellular munc18c levels can modulate glucose transport rate and GLUT4 translocation in 3T3L1 cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

response to organic substance

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

glucose homeostasis

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

14 February 2019

Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01326

determination method

positive regulation of peptidyl-tyrosine phosphorylation

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01326

Insulin, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01326

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000000220

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000000220

ENSMUSP00000101552

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000101552

ENSMUSP00000101553

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000101553

ENSMUSP00000101554

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000101554

ENSMUSP00000101550

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000101550

ENSMUSP00000101551

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000101551

ENSMUSP00000115147

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000115147

ENSMUSP00000124643

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000124643

ENSMUSP00000147425

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000147425

Sitelinks

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Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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