(Q14863583)

Apoptosis regulator, Bcl-2

1 reference

Apoptosis regulator, Bcl-2 protein, BH4 family

1 reference

Apoptosis regulator, Bcl-2, BH3 motif, conserved site, protein family

1 reference

Apoptosis regulator, Bcl-2, BH1 motif, conserved site, protein family

1 reference

Apoptosis regulator, Bcl-2, BH2 motif, conserved site, protein family

1 reference

Apoptosis regulator, Bcl-2, BH4 motif, conserved site, protein family

1 reference

protein phosphatase binding

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

Calcium-dependent interaction of calcineurin with Bcl-2 in neuronal tissue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

transcription factor binding

1 reference

14 February 2019

c-Myc is essential for urokinase plasminogen activator expression on hypoxia-induced vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

protein phosphatase 2A binding

IPI

1 reference

14 February 2019

PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

18 references

14 February 2019

Dual role of proapoptotic BAD in insulin secretion and beta cell survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Proapoptotic activity of ITM2B(s), a BH3-only protein induced upon IL-2-deprivation which interacts with Bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Involvement of heat shock protein (Hsp)90 beta but not Hsp90 alpha in antiapoptotic effect of CpG-B oligodeoxynucleotide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Endogenous HMGB1 regulates autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

IAN family critically regulates survival and development of T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Upregulation of Bcl2 inhibits apoptosis-driven BAX insertion but favors BAX relocalization in mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Deacetylation of p53 induces autophagy by suppressing Bmf expression

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

sequence-specific DNA binding

IPI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

protein heterodimerization activity

6 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

protein homodimerization activity

3 references

protein heterodimerization activity

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

5 references

14 February 2019

Role of BCL-2 in the survival and function of developing and mature sympathetic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Up-regulation of bax and down-regulation of bcl-2 is associated with kainate-induced apoptosis in mouse brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Differential regulation of bcl-2, bax, c-fos, junB, and krox-24 expression in the cerebellum of Purkinje cell degeneration mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

3 references

27 February 2018

Targeted Disruption of the PDZK1 Gene in Mice Causes Tissue-specific Depletion of the High Density Lipoprotein Receptor Scavenger Receptor Class B Type I and Altered Lipoprotein Metabolism

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

A novel transactivating factor that regulates interferon-gamma-dependent gene expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

5 references

14 February 2019

The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

8 references

27 February 2018

The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Sorting specificity of spermatogenic cell specific region of mouse hexokinase-s (mHk1-s)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Expression of Bcl-2 protein in murine neural cells in culture

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Bcl-2 overexpression abolishes early calcium waving preceding apoptosis in NIH-3T3 murine fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

7 references

14 February 2019

Role of BCL-2 in the survival and function of developing and mature sympathetic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Bcl-2 overexpression abolishes early calcium waving preceding apoptosis in NIH-3T3 murine fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Expression of Bcl-2 protein in murine neural cells in culture

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice

mitochondrial membranes

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

1 reference

14 February 2019

Expression of Bcl-2 protein in murine neural cells in culture

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

endoplasmic reticulum

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

integral component of membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

intracellular anatomical structure

3 references

27 February 2018

Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Pro- and anti-apoptotic members of the Bcl-2 family in skeletal muscle: a distinct role for Bcl-2 in later stages of myogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

mitochondrial outer membrane

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

protein-containing complex

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

8 references

14 February 2019

The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Sorting specificity of spermatogenic cell specific region of mouse hexokinase-s (mHk1-s)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Bcl-2 overexpression abolishes early calcium waving preceding apoptosis in NIH-3T3 murine fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Expression of Bcl-2 protein in murine neural cells in culture

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Targeted Disruption of the PDZK1 Gene in Mice Causes Tissue-specific Depletion of the High Density Lipoprotein Receptor Scavenger Receptor Class B Type I and Altered Lipoprotein Metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

A novel transactivating factor that regulates interferon-gamma-dependent gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

perinuclear region of cytoplasm

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

negative regulation of neuron apoptotic process

ISO

biological process

7 references

14 February 2019

Role of BCL-2 in the survival and function of developing and mature sympathetic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Differences in bcl-2- and bax-independent function in regulating apoptosis in sensory neuron populations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Patterns of cell death in mouse anteroventral cochlear nucleus neurons after unilateral cochlea removal

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Enhanced oxidative stress and altered antioxidants in brains of Bcl-2-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

intrinsic apoptotic signaling pathway in response to oxidative stress

1 reference

14 February 2019

Bcl2 retards G1/S cell cycle transition by regulating intracellular ROS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

Apoptosis during an early stage of nephrogenesis induces renal hypoplasia in bcl-2-deficient mice

ureteric bud development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

1 reference

14 February 2019

bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

1 reference

14 February 2019

Abnormal postpartum renal development and cystogenesis in the bcl-2 (-/-) mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

2 references

lymphocyte homeostasis

4 references

14 February 2019

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Polycystic kidney disease prevented by transgenic RNA interference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

response to steroid hormone

1 reference

14 February 2019

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

positive regulation of catalytic activity

1 reference

14 February 2019

c-Myc is essential for urokinase plasminogen activator expression on hypoxia-induced vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

3 references

14 February 2019

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

Apoptosis during an early stage of nephrogenesis induces renal hypoplasia in bcl-2-deficient mice

glomerulus development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

post-embryonic development

7 references

14 February 2019

bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Hair follicle apoptosis and Bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Bcl-2 and Bax function independently to regulate cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

regulation of protein localization

1 reference

14 February 2019

Nuclear localization of beta-catenin and loss of apical brush border actin in cystic tubules of bcl-2 -/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

negative regulation of ossification

1 reference

14 February 2019

Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

3 references

14 February 2019

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Bcl-XL and Bcl-2 repress a common pathway of cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

positive regulation of smooth muscle cell migration

1 reference

14 February 2019

c-Myc is essential for urokinase plasminogen activator expression on hypoxia-induced vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

negative regulation of G1/S transition of mitotic cell cycle

3 references

14 February 2019

Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Bcl2 retards G1/S cell cycle transition by regulating intracellular ROS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

T cell differentiation

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

B cell lineage commitment

1 reference

14 February 2019

Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

1 reference

14 February 2019

Targeted disruption of the bcl-2 gene in mice exacerbates focal ischemic brain injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

regulation of mitochondrial membrane permeability

1 reference

14 February 2019

Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

mesenchymal cell development

1 reference

14 February 2019

Apoptosis during an early stage of nephrogenesis induces renal hypoplasia in bcl-2-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

positive regulation of multicellular organism growth

1 reference

14 February 2019

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

animal organ morphogenesis

1 reference

14 February 2019

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

developmental pigmentation

3 references

14 February 2019

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

hair follicle morphogenesis

1 reference

14 February 2019

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

cell population proliferation

1 reference

14 February 2019

Differences in bcl-2- and bax-independent function in regulating apoptosis in sensory neuron populations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

negative regulation of autophagy

1 reference

14 February 2019

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

positive regulation of neuron maturation

1 reference

14 February 2019

Bcl-2 accelerates the maturation of early sensory neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

melanocyte differentiation

4 references

14 February 2019

Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Accelerated disappearance of melanocytes in bcl-2-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

negative regulation of myeloid cell apoptotic process

1 reference

14 February 2019

Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

cellular response to hypoxia

1 reference

14 February 2019

Bcl-2 protects neural cells from cyanide/aglycemia-induced lipid oxidation, mitochondrial injury, and loss of viability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

pigment granule organization

1 reference

14 February 2019

Accelerated disappearance of melanocytes in bcl-2-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

negative regulation of cell population proliferation

1 reference

14 February 2019

Diminished cell proliferation associated with the death-protective activity of Bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

6 references

14 February 2019

Bcl-2 prevents hippocampal cell death induced by the neuroleptic drug haloperidol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

regulation of apoptotic process

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Polycystic kidney disease prevented by transgenic RNA interference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

cellular response to organic substance

1 reference

14 February 2019

Apoptosis and related proteins in placenta of intrauterine fetal death in prostaglandin f receptor-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

3 references

14 February 2019

The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Bcl2 retards G1/S cell cycle transition by regulating intracellular ROS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

cellular response to glucose starvation

1 reference

14 February 2019

Bcl-2 protects neural cells from cyanide/aglycemia-induced lipid oxidation, mitochondrial injury, and loss of viability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

regulation of protein stability

1 reference

14 February 2019

Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

1 reference

14 February 2019

The bcl-2 knockout mouse exhibits marked changes in osteoblast phenotype and collagen deposition in bone as well as a mild growth plate phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

positive regulation of melanocyte differentiation

1 reference

14 February 2019

Indispensable role of Bcl2 in the development of the melanocyte stem cell

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

10 references

14 February 2019

bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Abnormal postpartum renal development and cystogenesis in the bcl-2 (-/-) mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Fulminant metanephric apoptosis and abnormal kidney development in bcl-2-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Nuclear localization of beta-catenin and loss of apical brush border actin in cystic tubules of bcl-2 -/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Polycystic kidney disease prevented by transgenic RNA interference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Suppression of ureteric bud apoptosis rescues nephron endowment and adult renal function in Pax2 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Bcl-2 and Bax function independently to regulate cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

1 reference

14 February 2019

Bcl-2 promotes regeneration of severed axons in mammalian CNS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

actin filament organization

1 reference

14 February 2019

Nuclear localization of beta-catenin and loss of apical brush border actin in cystic tubules of bcl-2 -/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

3 references

14 February 2019

Bcl-2 and Bax function independently to regulate cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Polycystic kidney disease prevented by transgenic RNA interference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Polycystic kidney disease prevented by transgenic RNA interference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

negative regulation of apoptotic signaling pathway

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

endoplasmic reticulum calcium ion homeostasis

1 reference

14 February 2019

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

response to oxidative stress

1 reference

14 February 2019

Bcl2 retards G1/S cell cycle transition by regulating intracellular ROS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

positive regulation of skeletal muscle fiber development

1 reference

14 February 2019

Pro- and anti-apoptotic members of the Bcl-2 family in skeletal muscle: a distinct role for Bcl-2 in later stages of myogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

lymphoid progenitor cell differentiation

1 reference

14 February 2019

Role of bcl-2 in the development of lymphoid cells from the hematopoietic stem cell

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

positive regulation of peptidyl-serine phosphorylation

1 reference

14 February 2019

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

CD8-positive, alpha-beta T cell lineage commitment

1 reference

14 February 2019

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

reactive oxygen species metabolic process

3 references

14 February 2019

Bcl2 retards G1/S cell cycle transition by regulating intracellular ROS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Developmental changes in antioxidant enzymes and oxidative damage in kidneys, liver and brain of bcl-2 knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Enhanced oxidative stress and altered antioxidants in brains of Bcl-2-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

negative regulation of retinal cell programmed cell death

1 reference

14 February 2019

Retinal ganglion cell loss after the period of naturally occurring cell death in bcl-2-/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

branching involved in ureteric bud morphogenesis

1 reference

14 February 2019

bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

negative regulation of cell growth

1 reference

14 February 2019

Bcl2 retards G1/S cell cycle transition by regulating intracellular ROS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

response to gamma radiation

4 references

14 February 2019

Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Effects of deficiency in p53 or bcl-2 on the sensitivity of clonogenic cells in the small intestine to low dose-rate irradiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

response to toxic substance

3 references

14 February 2019

PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

digestive tract morphogenesis

1 reference

14 February 2019

bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

Bcl-2 and Bax function independently to regulate cell death

male gonad development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

regulation of glycoprotein biosynthetic process

1 reference

14 February 2019

Alterations in cell-adhesive and migratory properties of proximal tubule and collecting duct cells from bcl-2 -/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

regulation of viral genome replication

1 reference

14 February 2019

Role of Bcl-2 expression for productive herpes simplex virus 2 replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

protein dephosphorylation

1 reference

14 February 2019

PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

cellular calcium ion homeostasis

1 reference

14 February 2019

Bcl-2 overexpression abolishes early calcium waving preceding apoptosis in NIH-3T3 murine fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

negative regulation of apoptotic process

29 references

27 February 2018

Proapoptotic BAX and BAK control multiple initiator caspases

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Evolutionary conservation of function among mammalian, avian, and viral homologs of the Bcl-2 oncoprotein

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Bcl-2 confers growth and survival advantage to interleukin 7-dependent early pre-B cells which become factor independent by a multistep process in culture

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

bcl-2 gene prevents apoptosis of basic fibroblast growth factor-deprived murine aortic endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

bcl-2 gene enables rescue from in vitro myelosuppression (bone marrow cell death) induced by chemotherapy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Apoptosis during an early stage of nephrogenesis induces renal hypoplasia in bcl-2-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Enhanced oxidative stress and altered antioxidants in brains of Bcl-2-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Susceptibility of cerebellar granule neurons derived from Bcl-2-deficient and transgenic mice to cell death

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Alterations in cell death and cell cycle progression in the UV-irradiated epidermis of bcl-2-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Abnormal postpartum renal development and cystogenesis in the bcl-2 (-/-) mouse

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Diminished cell proliferation associated with the death-protective activity of Bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Fulminant metanephric apoptosis and abnormal kidney development in bcl-2-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Retinal ganglion cell loss after the period of naturally occurring cell death in bcl-2-/- mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Bcl-2 is required for cranial sensory neuron survival at defined stages of embryonic development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Regulation of the lifespan in dendritic cell subsets

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Targeted Disruption of the PDZK1 Gene in Mice Causes Tissue-specific Depletion of the High Density Lipoprotein Receptor Scavenger Receptor Class B Type I and Altered Lipoprotein Metabolism

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Apoptosis and Bcl-2 expression in cultured murine splenic T cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Bax directly induces release of cytochrome c from isolated mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

Increased anxiety-like behaviors and mitochondrial dysfunction in mice with targeted mutation of the Bcl-2 gene: further support for the involvement of mitochondrial function in anxiety disorders

behavioral fear response

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

1 reference

14 February 2019

Ablation of bcl-2 gene expression decreases the numbers of oocytes and primordial follicles established in the post-natal female mouse gonad

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

regulation of cell-matrix adhesion

1 reference

14 February 2019

Alterations in cell-adhesive and migratory properties of proximal tubule and collecting duct cells from bcl-2 -/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

negative regulation of cell migration

1 reference

14 February 2019

Alterations in cell-adhesive and migratory properties of proximal tubule and collecting duct cells from bcl-2 -/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

regulation of autophagy

1 reference

14 February 2019

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

1 reference

14 February 2019

Polycystic kidney disease prevented by transgenic RNA interference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

ovarian follicle development

1 reference

14 February 2019

Ablation of bcl-2 gene expression decreases the numbers of oocytes and primordial follicles established in the post-natal female mouse gonad

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

negative regulation of calcium ion transport into cytosol

1 reference

14 February 2019

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

negative regulation of osteoblast proliferation

1 reference

14 February 2019

The bcl-2 knockout mouse exhibits marked changes in osteoblast phenotype and collagen deposition in bone as well as a mild growth plate phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

1 reference

14 February 2019

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

regulation of catalytic activity

1 reference

14 February 2019

Enhanced oxidative stress and altered antioxidants in brains of Bcl-2-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

peptidyl-threonine phosphorylation

1 reference

14 February 2019

Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

T cell lineage commitment

1 reference

14 February 2019

Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

response to hydrogen peroxide

1 reference

14 February 2019

Bcl2 retards G1/S cell cycle transition by regulating intracellular ROS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

cochlear nucleus development

1 reference

14 February 2019

Patterns of cell death in mouse anteroventral cochlear nucleus neurons after unilateral cochlea removal

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

Role of bcl-2 in the development of lymphoid cells from the hematopoietic stem cell

leukocyte homeostasis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

regulation of programmed cell death

1 reference

14 February 2019

Suppression of ureteric bud apoptosis rescues nephron endowment and adult renal function in Pax2 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

1 reference

14 February 2019

Bcl-2 promotes regeneration of severed axons in mammalian CNS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

Alterations in cell death and cell cycle progression in the UV-irradiated epidermis of bcl-2-deficient mice

regulation of cell cycle

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

regulation of mitochondrial membrane potential

1 reference

14 February 2019

Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

melanin metabolic process

1 reference

14 February 2019

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

Alterations in cell-adhesive and migratory properties of proximal tubule and collecting duct cells from bcl-2 -/- mice

focal adhesion assembly

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

immune system development

apoptotic mitochondrial changes

1 reference

14 February 2019

TCR-independent and caspase-independent apoptosis of murine thymocytes by CD24 cross-linking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

peptidyl-serine phosphorylation

1 reference

14 February 2019

Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

regulation of nitrogen utilization

1 reference

14 February 2019

Bcl-2 and Bax function independently to regulate cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

1 reference

14 February 2019

The bcl-2 knockout mouse exhibits marked changes in osteoblast phenotype and collagen deposition in bone as well as a mild growth plate phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

positive regulation of cell population proliferation

1 reference

27 February 2018

bcl-2 overexpression promotes myocyte proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

extrinsic apoptotic signaling pathway in absence of ligand

1 reference

27 February 2018

Proapoptotic activity of ITM2B(s), a BH3-only protein induced upon IL-2-deprivation which interacts with Bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

negative regulation of reactive oxygen species metabolic process

1 reference

14 February 2019

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

1 reference

14 February 2019

Alterations in cell death and cell cycle progression in the UV-irradiated epidermis of bcl-2-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

regulation of developmental pigmentation

1 reference

14 February 2019

Polycystic kidney disease prevented by transgenic RNA interference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

release of cytochrome c from mitochondria

1 reference

14 February 2019

Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

negative regulation of mitotic cell cycle

1 reference

14 February 2019

Bcl-2 and Bax function independently to regulate cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

transmembrane transport

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

intrinsic apoptotic signaling pathway in response to DNA damage

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

negative regulation of intrinsic apoptotic signaling pathway

3 references

2 references

27 February 2018

bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

27 February 2018

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

1 reference

14 February 2019

Alterations in cell-adhesive and migratory properties of proximal tubule and collecting duct cells from bcl-2 -/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

positive regulation of cell population proliferation

3 references

1 January 2018

Antisense oligonucleotides suppress B-cell lymphoma growth in a SCID-hu mouse model

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

1 January 2018

bcl-2 overexpression promotes myocyte proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417

intrinsic apoptotic signaling pathway in response to DNA damage

negative regulation of cardiac muscle cell apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine

ISO

T cell differentiation

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

negative regulation of apoptotic process

30 references

14 February 2019

Proapoptotic BAX and BAK control multiple initiator caspases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Evolutionary conservation of function among mammalian, avian, and viral homologs of the Bcl-2 oncoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

bcl-2 gene prevents apoptosis of basic fibroblast growth factor-deprived murine aortic endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Bcl-2 confers growth and survival advantage to interleukin 7-dependent early pre-B cells which become factor independent by a multistep process in culture

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

bcl-2 gene enables rescue from in vitro myelosuppression (bone marrow cell death) induced by chemotherapy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Diminished cell proliferation associated with the death-protective activity of Bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Retinal ganglion cell loss after the period of naturally occurring cell death in bcl-2-/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Susceptibility of cerebellar granule neurons derived from Bcl-2-deficient and transgenic mice to cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Enhanced oxidative stress and altered antioxidants in brains of Bcl-2-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Abnormal postpartum renal development and cystogenesis in the bcl-2 (-/-) mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Fulminant metanephric apoptosis and abnormal kidney development in bcl-2-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Alterations in cell death and cell cycle progression in the UV-irradiated epidermis of bcl-2-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Apoptosis during an early stage of nephrogenesis induces renal hypoplasia in bcl-2-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Bcl-2 is required for cranial sensory neuron survival at defined stages of embryonic development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Targeted Disruption of the PDZK1 Gene in Mice Causes Tissue-specific Depletion of the High Density Lipoprotein Receptor Scavenger Receptor Class B Type I and Altered Lipoprotein Metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Bax directly induces release of cytochrome c from isolated mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Apoptosis and Bcl-2 expression in cultured murine splenic T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Regulation of the lifespan in dendritic cell subsets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

extrinsic apoptotic signaling pathway in absence of ligand

ISO

positive regulation of cell population proliferation

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

Antisense oligonucleotides suppress B-cell lymphoma growth in a SCID-hu mouse model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

14 February 2019

bcl-2 overexpression promotes myocyte proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417

Apoptosis regulator, Bcl-2, BH4 motif, conserved site

has part(s)

1 reference

Apoptosis regulator, Bcl-2, BH2 motif, conserved site

1 reference

Apoptosis regulator, Bcl-2, BH1 motif, conserved site

1 reference

Apoptosis regulator, Bcl-2 protein, BH4

1 reference

Apoptosis regulator, Bcl-2, BH3 motif, conserved site

1 reference