(Q14864467)

http://www.ebi.ac.uk/interpro/protein/P18893

four-helical cytokine-like, core

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18893

Interleukin-10, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

5 references

9 May 2019

CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

9 May 2019

MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

9 May 2019

Cutting edge: FISP (IL-4-induced secreted protein), a novel cytokine-like molecule secreted by Th2 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

interleukin-10 receptor binding

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18893&geneProductId=UniProtKB:P18893

protein dimerization activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18893&geneProductId=UniProtKB:P18893

13 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

9 May 2019

Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

9 May 2019

HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

9 May 2019

NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

9 May 2019

Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

9 May 2019

A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

9 May 2019

Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

9 May 2019

Critical role of NOD2 in regulating the immune response to Staphylococcus aureus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

9 May 2019

CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

9 May 2019

Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

9 May 2019

Pregnancy specific glycoprotein 18 induces IL-10 expression in murine macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

negative regulation of chronic inflammatory response to antigenic stimulus

biological process

1 reference

9 May 2019

Interleukin-10 ameliorates the outcome of Staphylococcus aureus arthritis by promoting bacterial clearance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

positive regulation of MHC class II biosynthetic process

1 reference

9 May 2019

MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

negative regulation of interferon-gamma production

1 reference

9 May 2019

Interleukin-10 ameliorates the outcome of Staphylococcus aureus arthritis by promoting bacterial clearance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

response to inactivity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

cellular response to hepatocyte growth factor stimulus

1 reference

9 May 2019

Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

cellular response to estradiol stimulus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

response to organic substance

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

response to carbon monoxide

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

negative regulation of myeloid dendritic cell activation

1 reference

9 May 2019

CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

response to lipopolysaccharide

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

branching involved in labyrinthine layer morphogenesis

1 reference

9 May 2019

Altered placental development in interleukin-10 null mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

defense response to bacterium

1 reference

9 May 2019

A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

negative regulation of tumor necrosis factor production

1 reference

9 May 2019

Interleukin-10 ameliorates the outcome of Staphylococcus aureus arthritis by promoting bacterial clearance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

cellular response to lipopolysaccharide

3 references

9 May 2019

MicroRNA-98 negatively regulates IL-10 production and endotoxin tolerance in macrophages after LPS stimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

9 May 2019

Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

9 May 2019

IL-10-induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

positive regulation of transcription by RNA polymerase II

1 reference

9 May 2019

Enhancer-mediated control of macrophage-specific arginase I expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

negative regulation of interleukin-12 production

1 reference

9 May 2019

CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

defense response to protozoan

1 reference

9 May 2019

Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

regulation of synapse organization

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18893&geneProductId=UniProtKB:P18893

regulation of sensory perception of pain

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18893&geneProductId=UniProtKB:P18893

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

negative regulation of sensory perception of pain

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18893&geneProductId=UniProtKB:P18893

negative regulation of cytokine production

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18893&geneProductId=UniProtKB:P18893

negative regulation of cell population proliferation

1 reference

9 May 2019

IL-10 Accelerates Re-Endothelialization and Inhibits Post-Injury Intimal Hyperplasia following Carotid Artery Denudation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

regulation of response to wounding

1 reference

9 May 2019

IL-10 Accelerates Re-Endothelialization and Inhibits Post-Injury Intimal Hyperplasia following Carotid Artery Denudation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

negative regulation of apoptotic process

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18893&geneProductId=UniProtKB:P18893

negative regulation of nitric oxide biosynthetic process

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18893&geneProductId=UniProtKB:P18893

positive regulation of macrophage activation

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18893&geneProductId=UniProtKB:P18893

positive regulation of endothelial cell proliferation

1 reference

9 May 2019

IL-10 Accelerates Re-Endothelialization and Inhibits Post-Injury Intimal Hyperplasia following Carotid Artery Denudation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

negative regulation of heterotypic cell-cell adhesion

1 reference

9 May 2019

IL-10 Accelerates Re-Endothelialization and Inhibits Post-Injury Intimal Hyperplasia following Carotid Artery Denudation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

positive regulation of cell cycle

1 reference

9 May 2019

IL-10 Accelerates Re-Endothelialization and Inhibits Post-Injury Intimal Hyperplasia following Carotid Artery Denudation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

negative regulation of vascular associated smooth muscle cell proliferation

1 reference

9 May 2019

IL-10 Accelerates Re-Endothelialization and Inhibits Post-Injury Intimal Hyperplasia following Carotid Artery Denudation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

negative regulation of endothelial cell apoptotic process

1 reference

9 May 2019

IL-10 Accelerates Re-Endothelialization and Inhibits Post-Injury Intimal Hyperplasia following Carotid Artery Denudation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

negative regulation of autophagy

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18893&geneProductId=UniProtKB:P18893

negative regulation of MHC class II biosynthetic process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18893&geneProductId=UniProtKB:P18893

positive regulation of receptor signaling pathway via JAK-STAT

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18893&geneProductId=UniProtKB:P18893

negative regulation of inflammatory response

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

9 May 2019

Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

positive regulation of pri-miRNA transcription by RNA polymerase II

1 reference

9 May 2019

IL-10-induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

negative regulation of hydrogen peroxide-induced neuron death

1 reference

9 May 2019

WNT5A signaling contributes to Aβ-induced neuroinflammation and neurotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

positive regulation of sprouting angiogenesis

1 reference

9 May 2019

Negative Regulation of miR-375 by Interleukin-10 Enhances Bone Marrow-Derived Progenitor Cell-Mediated Myocardial Repair and Function After Myocardial Infarction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18893

Interleukin-10, conserved site

has part(s)

1 reference

stated in

InterPro Release 71.0