(Q14864519)

English

Interleukin 2

mammalian protein found in Mus musculus

TCGF
interleukin-2
Il2
T-cell growth factor

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P04351

four-helical cytokine-like, core

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P04351

Interleukin-2, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

cytokine activity

determination method

7 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

IL-4 induces IL-2 receptor p75 beta-chain gene expression and IL-2-dependent proliferation in mouse T lymphocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

interleukin-2 receptor binding

determination method

6 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

IL-4 induces IL-2 receptor p75 beta-chain gene expression and IL-2-dependent proliferation in mouse T lymphocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

growth factor activity

determination method

2 references

carbohydrate binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

kappa-type opioid receptor binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

glycosphingolipid binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

extracellular region

determination method

2 references

extracellular space

determination method

13 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

Altered antigen presentation in mice lacking H2-O

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

The specificity and orientation of a TCR to its peptide-MHC class II ligands

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

Differential T cell costimulatory requirements in CD28-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

Critical role of NOD2 in regulating the immune response to Staphylococcus aureus

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

biological process

adaptive immune response

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

immune system process

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

positive regulation of interferon-gamma production

determination method

1 reference

14 February 2019

FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

negative regulation of lymphocyte proliferation

determination method

1 reference

14 February 2019

A function for interleukin 2 in Foxp3-expressing regulatory T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

regulation of T cell homeostatic proliferation

determination method

1 reference

14 February 2019

A function for interleukin 2 in Foxp3-expressing regulatory T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

immune response

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

extrinsic apoptotic signaling pathway in absence of ligand

determination method

1 reference

14 February 2019

Proapoptotic activity of ITM2B(s), a BH3-only protein induced upon IL-2-deprivation which interacts with Bcl-2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

positive regulation of isotype switching to IgG isotypes

determination method

1 reference

14 February 2019

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

14 February 2019

Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

positive regulation of activated T cell proliferation

determination method

5 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

negative regulation of T-helper 17 cell differentiation

determination method

1 reference

14 February 2019

MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

positive regulation of tyrosine phosphorylation of STAT protein

determination method

3 references

regulation of signaling receptor activity

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

negative regulation of protein phosphorylation

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

positive regulation of protein phosphorylation

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

G protein-coupled receptor signaling pathway

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

positive regulation of cytosolic calcium ion concentration

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

protein kinase C-activating G protein-coupled receptor signaling pathway

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

positive regulation of T cell proliferation

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

14 February 2019

IL-4 induces IL-2 receptor p75 beta-chain gene expression and IL-2-dependent proliferation in mouse T lymphocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

response to ethanol

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

positive regulation of T cell differentiation

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

positive regulation of regulatory T cell differentiation

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

negative regulation of heart contraction

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

positive regulation of dendritic spine development

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

determination method

Interleukin-2, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P04351

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000029275

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000029275

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q14864519&oldid=2023061326"