(Q14865673)

English

Forkhead box P3

mammalian protein found in Mus musculus

scurfy
Scurfin
forkhead box protein P3
Foxp3

In more languages

Statements

1 reference

12 September 2018

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Winged helix DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99JB6

Winged helix-like DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99JB6

FOXP, coiled-coil domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger C2H2-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Fork head domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Fork head domain conserved site 2, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

12 September 2018

UniProt protein ID

1 reference

12 September 2018

UniProt protein ID

molecular function

NFAT protein binding

determination method

sequence-specific DNA binding

determination method

5 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

protein homodimerization activity

determination method

4 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

transcription corepressor activity

determination method

1 reference

9 May 2019

Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

DNA-binding transcription factor activity

determination method

5 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

metal ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

protein binding

determination method

3 references

9 May 2019

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

nucleic acid binding

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

determination method

1 reference

5 June 2018

Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99JB6&geneProductId=UniProtKB:Q99JB6

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

9 May 2019

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

1 reference

9 May 2019

Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

intracellular anatomical structure

determination method

1 reference

5 June 2018

A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic protein 1 in lymphopoiesis and innate immunity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99JB6&geneProductId=UniProtKB:Q99JB6

determination method

determination method

8 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

biological process

negative regulation of interleukin-10 production

determination method

4 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

T cell mediated immunity

determination method

1 reference

9 May 2019

The amount of scurfin protein determines peripheral T cell number and responsiveness

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

tolerance induction to self antigen

determination method

1 reference

9 May 2019

Regulatory T cell lineage specification by the forkhead transcription factor foxp3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

negative regulation of interferon-gamma production

determination method

8 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

determination method

5 references

9 May 2019

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Foxp3+ regulatory T cells maintain immune homeostasis in the skin

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Where CD4+CD25+ T reg cells impinge on autoimmune diabetes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

regulation of transcription, DNA-templated

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

regulation of isotype switching to IgG isotypes

determination method

1 reference

9 May 2019

Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

regulatory T cell differentiation

determination method

3 references

14 February 2019

Regulatory T cell lineage specification by the forkhead transcription factor foxp3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

14 February 2019

Control of regulatory T cell development by the transcription factor Foxp3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

14 February 2019

Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

negative regulation of interleukin-4 production

determination method

5 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

positive regulation of immature T cell proliferation in thymus

determination method

1 reference

9 May 2019

The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

regulation of transcription by RNA polymerase II

determination method

1 reference

9 May 2019

IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

positive regulation of regulatory T cell differentiation

determination method

negative regulation of interleukin-6 production

determination method

1 reference

9 May 2019

Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

myeloid cell homeostasis

determination method

1 reference

9 May 2019

Cellular and molecular characterization of the scurfy mouse mutant

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

cytokine production

determination method

5 references

9 May 2019

Disease in the scurfy (sf) mouse is associated with overexpression of cytokine genes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Cellular and molecular characterization of the scurfy mouse mutant

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

CD4+CD8- T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

CD4+CD8- T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

negative regulation of CREB transcription factor activity

determination method

positive regulation of peripheral T cell tolerance induction

determination method

1 reference

9 May 2019

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

response to virus

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

negative regulation of isotype switching to IgE isotypes

determination method

1 reference

9 May 2019

Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

B cell homeostasis

determination method

1 reference

9 May 2019

Cellular and molecular characterization of the scurfy mouse mutant

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

negative regulation of transcription by RNA polymerase II

determination method

4 references

9 May 2019

The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

positive regulation of T cell tolerance induction

determination method

1 reference

9 May 2019

Foxp3 controls autoreactive T cell activation through transcriptional regulation of early growth response genes and E3 ubiquitin ligase genes, independently of thymic selection

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

negative regulation of gene expression

determination method

1 reference

9 May 2019

Deletion of Fanca or Fancd2 dysregulates Treg in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

transcription, DNA-templated

determination method

1 reference

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99JB6&geneProductId=UniProtKB:Q99JB6

determination method

positive regulation of interleukin-4 production

determination method

1 reference

9 May 2019

An intrinsic mechanism predisposes Foxp3-expressing regulatory T cells to Th2 conversion in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

negative regulation of DNA-binding transcription factor activity

determination method

positive regulation of histone acetylation

determination method

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

positive regulation of transcription, DNA-templated

determination method

5 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

positive regulation of transforming growth factor beta1 production

determination method

1 reference

9 May 2019

Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

negative regulation of T cell proliferation

determination method

7 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Foxp3 controls autoreactive T cell activation through transcriptional regulation of early growth response genes and E3 ubiquitin ligase genes, independently of thymic selection

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

How defects in central tolerance impinge on a deficiency in regulatory T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

negative regulation of immune response

determination method

positive regulation of T cell anergy

determination method

1 reference

9 May 2019

Foxp3 controls autoreactive T cell activation through transcriptional regulation of early growth response genes and E3 ubiquitin ligase genes, independently of thymic selection

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

negative regulation of T cell cytokine production

determination method

CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment

determination method

1 reference

9 May 2019

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

tolerance induction

determination method

1 reference

9 May 2019

Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

regulation of T cell anergy

determination method

1 reference

9 May 2019

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

negative regulation of tumor necrosis factor production

determination method

1 reference

9 May 2019

Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

negative regulation of interleukin-17 production

determination method

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

negative regulation of transcription, DNA-templated

determination method

5 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

negative regulation of NF-kappaB transcription factor activity

determination method

regulation of immunoglobulin production

determination method

1 reference

9 May 2019

Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

negative regulation of interleukin-2 production

determination method

7 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

negative regulation of histone acetylation

determination method

1 reference

9 May 2019

Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

negative regulation of inflammatory response

determination method

1 reference

9 May 2019

How defects in central tolerance impinge on a deficiency in regulatory T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

T cell activation

determination method

4 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Cellular and molecular characterization of the scurfy mouse mutant

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

negative regulation of T-helper 17 cell differentiation

determination method

positive regulation of transcription by RNA polymerase II

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Foxp3 controls autoreactive T cell activation through transcriptional regulation of early growth response genes and E3 ubiquitin ligase genes, independently of thymic selection

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

negative regulation of cell population proliferation

determination method

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

14 February 2019

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

14 February 2019

Foxp3+ regulatory T cells maintain immune homeostasis in the skin

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

anatomical structure morphogenesis

determination method

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99JB6&geneProductId=UniProtKB:Q99JB6

determination method

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

positive regulation of regulatory T cell differentiation

determination method

5 references

9 May 2019

Regulatory T cell lineage specification by the forkhead transcription factor foxp3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

9 May 2019

Control of regulatory T cell development by the transcription factor Foxp3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99JB6

determination method

Identifiers

RefSeq protein ID

1 reference

14 September 2018

1 reference

14 September 2018

1 reference

14 September 2018

UniProt protein ID

1 reference

12 September 2018

UniProt protein ID

Ensembl protein ID

ENSMUSP00000041953

1 reference

ensembl Release 94

Ensembl protein ID

ENSMUSP00000041953

ENSMUSP00000111403

1 reference

ensembl Release 94

Ensembl protein ID

ENSMUSP00000111403

ENSMUSP00000111404

1 reference

ensembl Release 94

Ensembl protein ID

ENSMUSP00000111404

ENSMUSP00000111405

1 reference

ensembl Release 94

Ensembl protein ID

ENSMUSP00000111405

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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