Wikidata

(Q14876092)

English

Mechanistic target of rapamycin kinase

mammalian protein found in Mus musculus

  • mechanistic target of rapamycin (serine/threonine kinase)
  • Mechanistic target of rapamycin
  • FKBP-rapamycin associated protein (FRAP)
  • FKBP12-rapamycin complex-associated protein
  • serine/threonine-protein kinase mTOR
  • mammalian target of rapamycin
  • FK506 binding protein 12-rapamycin associated protein 1
  • rapamycin target protein 1
  • angiopoietin-like factor CDT6
  • FK506-binding protein 12-rapamycin complex-associated protein 1
  • RAPT1
  • Mtor
In more languages

Statements

part of
molecular function
protein serine/threonine kinase activity
determination method
IDA
IEA
ISO
7 references
retrieved
16 July 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JLN9&geneProductId=UniProtKB:Q9JLN9
determination method
ISO
retrieved
16 July 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q9JLN9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JLN9&geneProductId=UniProtKB:Q9JLN9
determination method
IEA
retrieved
16 July 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JLN9&geneProductId=UniProtKB:Q9JLN9
determination method
IEA
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JLN9&geneProductId=UniProtKB:Q9JLN9
determination method
IEA
retrieved
16 July 2018
stated in
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
GOA
curator
UniProt
UniProt protein ID
Q9JLN9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JLN9&geneProductId=UniProtKB:Q9JLN9
determination method
IDA
retrieved
16 July 2018
stated in
Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JLN9&geneProductId=UniProtKB:Q9JLN9
determination method
IDA
retrieved
16 July 2018
stated in
FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JLN9&geneProductId=UniProtKB:Q9JLN9
determination method
IDA
protein binding
determination method
IPI
19 references
retrieved
14 February 2019
stated in
PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR
GOA
curator
UniProt
UniProt protein ID
Q9JLN9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IPI
retrieved
14 February 2019
stated in
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
GOA
curator
UniProt
UniProt protein ID
Q9JLN9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IPI
retrieved
14 February 2019
stated in
5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia
GOA
curator
UniProt
UniProt protein ID
Q9JLN9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IPI
retrieved
14 February 2019
stated in
PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription
GOA
curator
UniProt
UniProt protein ID
Q9JLN9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IPI
retrieved
14 February 2019
stated in
mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
GOA
curator
UniProt
UniProt protein ID
Q9JLN9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IPI
retrieved
14 February 2019
stated in
Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IPI
retrieved
14 February 2019
stated in
PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IPI
retrieved
14 February 2019
stated in
Reduced juvenile long-term depression in tuberous sclerosis complex is mitigated in adults by compensatory recruitment of mGluR5 and Erk signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IPI
retrieved
14 February 2019
stated in
mTORC1 promotes survival through translational control of Mcl-1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IPI
retrieved
14 February 2019
stated in
Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IPI
retrieved
14 February 2019
stated in
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IPI
retrieved
14 February 2019
stated in
Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IPI
retrieved
14 February 2019
stated in
Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IPI
retrieved
14 February 2019
stated in
PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IPI
retrieved
14 February 2019
stated in
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IPI
retrieved
14 February 2019
stated in
mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IPI
retrieved
14 February 2019
stated in
Huntingtin functions as a scaffold for selective macroautophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IPI
retrieved
14 February 2019
stated in
mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IPI
retrieved
14 February 2019
stated in
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IPI
protein serine/threonine kinase activity
determination method
IBA
IDA
IEA
ISO
8 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9JLN9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IEA
retrieved
14 February 2019
stated in
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
GOA
curator
UniProt
UniProt protein ID
Q9JLN9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IDA
retrieved
14 February 2019
stated in
FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IDA
retrieved
14 February 2019
stated in
Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JLN9
determination method
IBA
cell component
biological process

Identifiers

 
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