(Q28507521)

English

Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation

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scholarly article

2 references

PubMed publication ID

24 January 2017

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15185396%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation (English)

2 references

PubMed publication ID

24 January 2017

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15185396%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

0 references

Mechanistic target of rapamycin kinase

1 reference

GOA release 2020-03-11

TSC complex subunit 1

1 reference

GOA release 2020-03-11

tuberous sclerosis

1 reference

based on heuristic

inferred from title

tuberous sclerosis 1

1 reference

based on heuristic

inferred from title

David H. Gutmann

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15185396%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

author name string

Wen Li

2

2 references

PubMed publication ID

24 January 2017

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15185396%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Chia-Ling Gau

4

2 references

PubMed publication ID

24 January 2017

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15185396%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Fuyuhiko Tamanoi

5

2 references

PubMed publication ID

24 January 2017

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15185396%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Erik J Uhlmann

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15185396%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Danielle K Scheidenhelm

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15185396%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

publication date

1 August 2004

2 references

PubMed publication ID

24 January 2017

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15185396%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

2 references

PubMed publication ID

24 January 2017

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15185396%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

47

2 references

PubMed publication ID

24 January 2017

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15185396%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

2

2 references

PubMed publication ID

24 January 2017

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15185396%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

180-188

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15185396%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

New developments in the neurobiology of the tuberous sclerosis complex

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

21 January 2018

Identification and characterization of the tuberous sclerosis gene on chromosome 16

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

21 January 2018

Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

21 January 2018

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Embryonic stem cell virus, a recombinant murine retrovirus with expression in embryonic stem cells

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel approach for expression cloning of small GTPases: identification, tissue distribution and chromosome mapping of the human homolog of rheb

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Tsc2 null murine neuroepithelial cells are a model for human tuber giant cells, and show activation of an mTOR pathway

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Drosophila Rheb GTPase is required for cell cycle progression and cell growth

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Akt regulates growth by directly phosphorylating Tsc2

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Two loci for tuberous sclerosis: one on 9q34 and one on 16p13.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Tuberous sclerosis complex consensus conference: revised clinical diagnostic criteria

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Rheb promotes cell growth as a component of the insulin/TOR signalling network

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Opinion: Searching for the elusive targets of farnesyltransferase inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Failure to farnesylate Rheb protein contributes to the enrichment of G0/G1 phase cells in the Schizosaccharomyces pombe farnesyltransferase mutant

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20036

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/GLIA.20036

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15185396%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

release_getudjnccjewjg7fowqwjde2vi

1 reference

https://api.fatcat.wiki/v0/release/getudjnccjewjg7fowqwjde2vi

24 November 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

2 references

PubMed publication ID

24 January 2017

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15185396%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

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