(Q28131740)

2

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Tianquan Zhu

3

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Jun Wu

4

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Kun-Liang Guan

The genetic basis of tuberous sclerosis.

5

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language of work or name

English

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publication date

September 2002

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published in

Nature Cell Biology

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volume

4

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page(s)

648-57

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issue

9

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cites work

1 reference

7 January 2021

Phenotypes of the tuberous sclerosis complex with a revision of diagnostic criteria

1 reference

7 January 2021

Identification and characterization of the tuberous sclerosis gene on chromosome 16

1 reference

7 January 2021

Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity

1 reference

7 January 2021

The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis

1 reference

7 January 2021

Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background

1 reference

7 January 2021

Germ-line mutational analysis of the TSC2 gene in 90 tuberous-sclerosis patients

1 reference

7 January 2021

A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice

1 reference

7 January 2021

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

1 reference

7 January 2021

gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle

1 reference

7 January 2021

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size.

1 reference

7 January 2021

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.

1 reference

7 January 2021

Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.

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7 January 2021

Genetic control of cell size

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7 January 2021

The genetic control of organ growth: insights from Drosophila.

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7 January 2021

The conserved phosphoinositide 3-kinase pathway determines heart size in mice

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7 January 2021

Akt/protein kinase B promotes organ growth in transgenic mice

1 reference

7 January 2021

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.

1 reference

7 January 2021

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

1 reference

7 January 2021

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

1 reference

7 January 2021

PI 3-kinase, mTOR, protein synthesis and cancer

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7 January 2021

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

1 reference

7 January 2021

TOR, a central controller of cell growth

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7 January 2021

4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle

1 reference

7 January 2021

The mRNA 5' cap-binding protein eIF4E and control of cell growth

1 reference

7 January 2021

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

1 reference

7 January 2021

Ribosomal S6 kinase signaling and the control of translation

1 reference

7 January 2021

The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

1 reference

7 January 2021

Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs

1 reference

7 January 2021

Comprehensive mutation analysis of TSC1 and TSC2-and phenotypic correlations in 150 families with tuberous sclerosis.

1 reference

7 January 2021

Cellular survival: a play in three Akts

1 reference

7 January 2021

The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila

1 reference

7 January 2021

The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination

1 reference

7 January 2021

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

1 reference

7 January 2021

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

1 reference

7 January 2021

Mammalian TOR: a homeostatic ATP sensor

1 reference

7 January 2021

Multiple independent inputs are required for activation of the p70 S6 kinase

1 reference

7 January 2021

Identification of a conserved motif required for mTOR signaling

1 reference

7 January 2021

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

1 reference

7 January 2021

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1 reference

7 January 2021

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1 reference

7 January 2021

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

1 reference

7 January 2021

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.

1 reference

7 January 2021

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

1 reference

7 January 2021

Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load

1 reference

7 January 2021

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

1 reference

7 January 2021

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

1 reference

7 January 2021

Identifiers

DOI

10.1038/NCB839

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

913858

1052520154

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913858

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference