(Q48495929)

12 February 2018

title

Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures. (English)

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12 February 2018

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Erik J Uhlmann

1

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12 February 2018

Michael Wong

2

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12 February 2018

Rebecca L Baldwin

3

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12 February 2018

M Livia Bajenaru

4

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12 February 2018

Hiroaki Onda

5

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12 February 2018

David J Kwiatkowski

6

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12 February 2018

Kelvin Yamada

7

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12 February 2018

David H Gutmann

8

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12 February 2018

publication date

1 September 2002

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12 February 2018

published in

Annals of Neurology

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12 February 2018

volume

52

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12 February 2018

page(s)

285-296

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12 February 2018

issue

3

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12 February 2018

Tuberous sclerosis complex consensus conference: revised clinical diagnostic criteria

cites work

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Cortical tuber count: a biomarker indicating neurologic severity of tuberous sclerosis complex

21 January 2018

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Two loci for tuberous sclerosis: one on 9q34 and one on 16p13.

21 January 2018

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Identification and characterization of the tuberous sclerosis gene on chromosome 16

21 January 2018

1 reference

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

21 January 2018

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Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

21 January 2018

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Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin

21 January 2018

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The TSC1 gene product, hamartin, negatively regulates cell proliferation

21 January 2018

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Inhibitors of mammalian G1 cyclin-dependent kinases

21 January 2018

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The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression.

21 January 2018

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Translational control of p27Kip1 accumulation during the cell cycle

21 January 2018

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The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

21 January 2018

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Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2

21 January 2018

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Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (Tsc2) gene and its C-terminal region

21 January 2018

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Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells.

21 January 2018

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Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity

21 January 2018

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The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis

21 January 2018

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A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice

21 January 2018

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Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background

21 January 2018

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Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation.

21 January 2018

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Dual fluorescent in situ hybridization and immunohistochemical detection with tyramide signal amplification

21 January 2018

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The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination

21 January 2018

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Alterations in the rap1 signaling pathway are common in human gliomas.

21 January 2018

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Expression of the tuberous sclerosis complex gene products, hamartin and tuberin, in central nervous system tissues.

21 January 2018

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Nestin-EGFP transgenic mice: visualization of the self-renewal and multipotency of CNS stem cells.

21 January 2018

1 reference

New views on synapse-glia interactions

21 January 2018

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CNS synaptogenesis promoted by glia-derived cholesterol

21 January 2018

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Studies on rat sympathetic neurons developing in cell culture. II. Synaptic mechanisms

21 January 2018

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Synaptic efficacy enhanced by glial cells in vitro.

21 January 2018

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Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

21 January 2018

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Role of sodium and potassium ions in regulation of glucose metabolism in cultured astroglia.

21 January 2018

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Evidence for glutamate-mediated activation of hippocampal neurons by glial calcium waves.

21 January 2018

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Evidence of abnormal differentiation in giant cells of tuberous sclerosis.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ANA.10283

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12 February 2018

PubMed ID

12205640

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12 February 2018