(Q48592496)

English

Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells.

scientific article published in June 2002

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12037687%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12037687%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

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tuberous sclerosis

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based on heuristic

inferred from title

tuberous sclerosis 1

1 reference

based on heuristic

inferred from title

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Stephen P Burke

4

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9 November 2019

David H. Gutmann

8

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9 November 2019

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Erik J Uhlmann

1

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9 November 2019

Anthony J Apicelli

2

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9 November 2019

Rebecca L Baldwin

3

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9 November 2019

M Livia Bajenaru

5

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9 November 2019

Hiroaki Onda

6

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9 November 2019

David Kwiatkowski

7

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9 November 2019

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1 June 2002

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9 November 2019

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9 November 2019

21

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9 November 2019

25

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9 November 2019

4050-4059

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9 November 2019

https://scigraph.springernature.com/pub.10.1038/sj.onc.1205435

0 references

Mitogenic and oncogenic properties of the small G protein Rap1b

1 reference

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21 January 2018

Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes

1 reference

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New developments in the neurobiology of the tuberous sclerosis complex

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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Molecular profile of reactive astrocytes--implications for their role in neurologic disease

1 reference

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A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

1 reference

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21 January 2018

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

1 reference

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21 January 2018

Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients.

1 reference

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21 January 2018

Functional analysis of neurofibromatosis 2 (NF2) missense mutations

1 reference

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Alterations in the rap1 signaling pathway are common in human gliomas.

1 reference

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21 January 2018

Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation

1 reference

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21 January 2018

Expression of the tuberous sclerosis complex gene products, hamartin and tuberin, in central nervous system tissues.

1 reference

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21 January 2018

A cell cycle-regulated inhibitor of cyclin-dependent kinases

1 reference

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21 January 2018

Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (Tsc2) gene and its C-terminal region

1 reference

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21 January 2018

Tumor spectrum analysis in p53-mutant mice

1 reference

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21 January 2018

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

1 reference

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21 January 2018

Multifocal alveolar hyperplasia associated with lymphangioleiomyomatosis in tuberous sclerosis

1 reference

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CNS stem cells express a new class of intermediate filament protein

1 reference

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21 January 2018

The GAP-related domain of tuberin, the product of the TSC2 gene, is a target for missense mutations in tuberous sclerosis

1 reference

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21 January 2018

The TSC1 gene product, hamartin, negatively regulates cell proliferation

1 reference

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21 January 2018

Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin

1 reference

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21 January 2018

Survey of somatic mutations in tuberous sclerosis complex (TSC) hamartomas suggests different genetic mechanisms for pathogenesis of TSC lesions

1 reference

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21 January 2018

Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background

1 reference

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21 January 2018

Molecular analysis of the TSC1 and TSC2 tumour suppressor genes in sporadic glial and glioneuronal tumours.

1 reference

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21 January 2018

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

1 reference

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21 January 2018

Two loci for tuberous sclerosis: one on 9q34 and one on 16p13.

1 reference

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21 January 2018

Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects

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21 January 2018

Region-specific astrogliosis in brains of mice heterozygous for mutations in the neurofibromatosis type 1 (Nf1) tumor suppressor

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21 January 2018

Tuberous sclerosis complex consensus conference: revised clinical diagnostic criteria

1 reference

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21 January 2018

Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2

1 reference

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21 January 2018

Expression of Rab GTPases using recombinant vaccinia viruses

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21 January 2018

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

1 reference

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21 January 2018

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205435

21 January 2018

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

1 reference

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21 January 2018

Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity

1 reference

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21 January 2018

Reduced TSC2 RNA and protein in sporadic astrocytomas and ependymomas.

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21 January 2018

Tuberous sclerosis-like lesions in epileptogenic human neocortex lack allelic loss at the TSC1 and TSC2 regions.

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21 January 2018

The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis

1 reference

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21 January 2018

Synergistic effect of intrastriatal co-administration of L-NAME and quinolinic acid

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Tuberin-dependent membrane localization of polycystin-1: a functional link between polycystic kidney disease and the TSC2 tumor suppressor gene

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7 January 2021

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Identification and characterization of the tuberous sclerosis gene on chromosome 16

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7 January 2021

based on heuristic

inferred from DOI database lookup

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