(Q14908117)

http://www.ebi.ac.uk/interpro/protein/Q9EP53

Armadillo-type fold

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9EP53

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

25 May 2022

1 reference

25 May 2022

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

protein N-terminus binding

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

4 references

14 February 2019

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

ATPase inhibitor activity

IPI

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

3 references

3 references

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

perinuclear region of cytoplasm

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

memory T cell differentiation

biological process

1 reference

14 February 2019

Tsc1 promotes the differentiation of memory CD8+ T cells via orchestrating the transcriptional and metabolic programs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

Tsc1 promotes the differentiation of memory CD8+ T cells via orchestrating the transcriptional and metabolic programs

adaptive immune response

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

1 reference

14 February 2019

A mouse model of tuberous sclerosis 1 showing background specific early post-natal mortality and metastatic renal cell carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

regulation of GTPase activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9EP53&geneProductId=UniProtKB:Q9EP53

cardiac muscle cell differentiation

1 reference

14 February 2019

A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

1 reference

14 February 2019

Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

nervous system development

1 reference

14 February 2019

A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

regulation of cell cycle

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

potassium ion transport

IGI

negative regulation of TOR signaling

4 references

14 February 2019

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

negative regulation of insulin receptor signaling pathway

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

1 reference

14 February 2019

A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

cell projection organization

1 reference

14 February 2019

Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

cerebral cortex development

1 reference

14 February 2019

A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

1 reference

14 February 2019

A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

1 reference

14 February 2019

The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

regulation of protein kinase activity

1 reference

14 February 2019

Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival

IGI

hippocampus development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

negative regulation of cell size

5 references

14 February 2019

Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

Glutathione metabolism in long-living Ames dwarf mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

negative regulation of cell population proliferation

IGI

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

regulation of actin cytoskeleton organization

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9EP53&geneProductId=UniProtKB:Q9EP53

protein stabilization

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

adult locomotory behavior

negative regulation of macroautophagy

negative regulation of ATP-dependent activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EP53