(Q28506116)

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A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival

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scholarly article

1 reference

PubMed publication ID

24 January 2017

A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival (English)

1 reference

PubMed publication ID

24 January 2017

TSC complex subunit 1

1 reference

GOA release 2020-03-11

tuberous sclerosis

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672762&resulttype=core&format=json

16 May 2020

author name string

Lynsey Meikle

1

2 references

PubMed publication ID

24 January 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672762&resulttype=core&format=json

16 May 2020

Hiroaki Onda

3

2 references

PubMed publication ID

24 January 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672762&resulttype=core&format=json

16 May 2020

Kristen Pollizzi

4

2 references

PubMed publication ID

24 January 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672762&resulttype=core&format=json

16 May 2020

Alexander Rotenberg

5

2 references

PubMed publication ID

24 January 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672762&resulttype=core&format=json

16 May 2020

Delia M Talos

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672762&resulttype=core&format=json

16 May 2020

Frances E Jensen

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672762&resulttype=core&format=json

16 May 2020

David J Kwiatkowski

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672762&resulttype=core&format=json

16 May 2020

language of work or name

0 references

publication date

23 May 2007

1 reference

PubMed publication ID

24 January 2017

Journal of Neuroscience

2 references

PubMed publication ID

24 January 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672762&resulttype=core&format=json

16 May 2020

27

2 references

PubMed publication ID

24 January 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672762&resulttype=core&format=json

16 May 2020

21

2 references

PubMed publication ID

24 January 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672762&resulttype=core&format=json

16 May 2020

5546-5558

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672762&resulttype=core&format=json

16 May 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6672762/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axonal control of oligodendrocyte development

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular genetic advances in tuberous sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Survey of somatic mutations in tuberous sclerosis complex (TSC) hamartomas suggests different genetic mechanisms for pathogenesis of TSC lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Widespread anatomical abnormalities of grey and white matter structure in tuberous sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenesis of hereditary tumors: beyond the "two-hit" hypothesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tsc2 null murine neuroepithelial cells are a model for human tuber giant cells, and show activation of an mTOR pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tuberous sclerosis: from tubers to mTOR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired glial glutamate transport in a mouse tuberous sclerosis epilepsy model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of tuberin as a novel mechanism for somatic inactivation of the tuberous sclerosis complex proteins in brain lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression profiling in tuberous sclerosis complex (TSC) knockout mouse astrocytes to characterize human TSC brain pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphology of cerebral lesions in the Eker rat model of tuberous sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin signaling pathways in cortical dysplasia and TSC-tubers: tissue microarray analysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mTOR cascade activation distinguishes tubers from focal cortical dysplasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A glycosynapse in myelin?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain abnormalities in tuberous sclerosis complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autism and tuberous sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Managing epilepsy in tuberous sclerosis complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular pathogenesis of tuber formation in tuberous sclerosis complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mouse model of cardiac rhabdomyoma generated by loss of Tsc1 in ventricular myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysregulation of the TSC-mTOR pathway in human disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mTOR, translational control and human disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New chronic EEG electrode for critical/intensive care unit monitoring.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmental origin of subependymal giant cell astrocytoma in tuberous sclerosis complex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Consensus clinical guidelines for the assessment of cognitive and behavioural problems in Tuberous Sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disruption of cortical development as a consequence of repetitive pilocarpine-induced status epilepticus in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Magnetization transfer ratio measurements of the brain in children with tuberous sclerosis complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Local translation of RhoA regulates growth cone collapse

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growing roles for the mTOR pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NG2-expressing cells as oligodendrocyte progenitors in the normal and demyelinated adult central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myelin-associated inhibitors regulate cofilin phosphorylation and neuronal inhibition through LIM kinase and Slingshot phosphatase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myelin under construction -- teamwork required

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmental regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor subunit expression in forebrain and relationship to regional susceptibility to hypoxic/ischemic injury. I. Rodent cerebral white matter and cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypothalamic mTOR signaling regulates food intake

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuron-glia communication in the control of oligodendrocyte function and myelin biogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neocortical hyperexcitability in a human case of tuberous sclerosis complex and mice lacking neuronal expression of TSC1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transient patterns of GAP-43 expression during the formation of barrels in the rat somatosensory cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fine structure of atypical cells in tuberous sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fine structure of cortical tubers in tuberous sclerosis: a Golgi study

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inverse patterns of myelination and GAP-43 expression in the adult CNS: neurite growth inhibitors as regulators of neuronal plasticity?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tuber and subependymal giant cell astrocytoma associated with tuberous sclerosis: an immunohistochemical, ultrastructural, and immunoelectron and microscopic study

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GAP-43: an intrinsic determinant of neuronal development and plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subependymal astrocytic hamartomas in the Eker rat model of tuberous sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoclonal antibodies SMI 311 and SMI 312 as tools to investigate the maturation of nerve cells and axonal patterns in human fetal brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17522300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.5540-06.2007

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672762&resulttype=core&format=json

16 May 2020

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672762&resulttype=core&format=json

16 May 2020

PubMed publication ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672762&resulttype=core&format=json

16 May 2020

ResearchGate publication ID

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