(Q36313189)

13 August 2017

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title

Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease (English)

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13 August 2017

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Aristotelis Astrinidis

series ordinal

1

object named as

Aristotelis Astrinidis

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13 August 2017

Elizabeth P Henske

2

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13 August 2017

language of work or name

English

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publication date

1 November 2005

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13 August 2017

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13 August 2017

volume

24

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13 August 2017

issue

50

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13 August 2017

page(s)

7475-7481

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Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B

13 August 2017

cites work

1 reference

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Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis

21 January 2018

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Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

21 January 2018

1 reference

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Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs

21 January 2018

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Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

21 January 2018

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Estrogen-induced smooth muscle cell growth is regulated by tuberin and associated with altered activation of platelet-derived growth factor receptor-beta and ERK-1/2

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase

21 January 2018

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Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton

21 January 2018

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Isotype-specific functions of Raf kinases

21 January 2018

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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

21 January 2018

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Tuberous sclerosis gene 2 product modulates transcription mediated by steroid hormone receptor family members

21 January 2018

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Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

21 January 2018

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Comprehensive mutation analysis of TSC1 and TSC2-and phenotypic correlations in 150 families with tuberous sclerosis.

21 January 2018

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Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

Comprehensive mutational analysis of the TSC1 gene: observations on frequency of mutation, associated features, and nonpenetrance

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

The tuberous sclerosis 2 gene product can localize to nuclei in a phosphorylation-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

Survey of somatic mutations in tuberous sclerosis complex (TSC) hamartomas suggests different genetic mechanisms for pathogenesis of TSC lesions

21 January 2018

1 reference

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A calmodulin binding site in the tuberous sclerosis 2 gene product is essential for regulation of transcription events and is altered by mutations linked to tuberous sclerosis and lymphangioleiomyomatosis

21 January 2018

1 reference

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Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

21 January 2018

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Mutation analysis of the TSC1 and TSC2 genes in Japanese patients with pulmonary lymphangioleiomyomatosis

21 January 2018

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Evidence that lymphangiomyomatosis is caused by TSC2 mutations: chromosome 16p13 loss of heterozygosity in angiomyolipomas and lymph nodes from women with lymphangiomyomatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Germ-line mutational analysis of the TSC2 gene in 90 tuberous-sclerosis patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

9q34 loss of heterozygosity in a tuberous sclerosis astrocytoma suggests a growth suppressor-like activity also for the TSC1 gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma

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7 January 2021

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Phosphorylation of tuberin as a novel mechanism for somatic inactivation of the tuberous sclerosis complex proteins in brain lesions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

The genetic basis of kidney cancer: why is tuberous sclerosis complex often overlooked?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Loss of heterozygosity in the tuberous sclerosis (TSC2) region of chromosome band 16p13 occurs in sporadic as well as TSC-associated renal angiomyolipomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Estrogen stimulation and tamoxifen inhibition of leiomyoma cell growth in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

TSC2 mediates cellular energy response to control cell growth and survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Recurrent lymphangiomyomatosis after transplantation: genetic analyses reveal a metastatic mechanism.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Renal angiomyolipomas from patients with sporadic lymphangiomyomatosis contain both neoplastic and non-neoplastic vascular structures

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Effects of rapamycin in the Eker rat model of tuberous sclerosis complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Hormone receptors in pulmonary lymphangiomyomatosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Mutation and cancer: statistical study of retinoblastoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Efficacy of a rapamycin analog (CCI-779) and IFN-gamma in tuberous sclerosis mouse models

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Frequent estrogen and progesterone receptor immunoreactivity in renal angiomyolipomas from women with pulmonary lymphangioleiomyomatosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Aberrant beta-catenin signaling in tuberous sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Phosphorylation and binding partner analysis of the TSC1-TSC2 complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Distinct effects of single amino-acid changes to tuberin on the function of the tuberin-hamartin complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Akt regulates growth by directly phosphorylating Tsc2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Aspects of tuberous sclerosis complex (TSC) protein function in the brain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Mutational analysis of the TSC1 and TSC2 genes in a diagnostic setting: genotype--phenotype correlations and comparison of diagnostic DNA techniques in Tuberous Sclerosis Complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Identification and characterization of the tuberous sclerosis gene on chromosome 16

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Cross-talk between tuberin, calmodulin, and estrogen signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Estradiol and tamoxifen stimulate LAM-associated angiomyolipoma cell growth and activate both genomic and nongenomic signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209090

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209090

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13 August 2017

1 reference