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Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent
scientific journal article
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scholarly article
1 reference
stated in
PubMed
PubMed ID
12403809
retrieved
31 January 2017
title
Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent
(English)
1 reference
stated in
PubMed
PubMed ID
12403809
retrieved
31 January 2017
main subject
Tuberin
1 reference
stated in
GOA release 2020-03-11
tuberous sclerosis
1 reference
based on heuristic
inferred from title
tuberous sclerosis 1
1 reference
based on heuristic
inferred from title
author
Angela Hodges
object named as
Angela Hodges
series ordinal
6
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author name string
Anja Jaeschke
series ordinal
1
1 reference
stated in
PubMed
PubMed ID
12403809
retrieved
31 January 2017
Joerg Hartkamp
series ordinal
2
1 reference
stated in
PubMed
PubMed ID
12403809
retrieved
31 January 2017
Masao Saitoh
series ordinal
3
1 reference
stated in
PubMed
PubMed ID
12403809
retrieved
31 January 2017
Wendy Roworth
series ordinal
4
1 reference
stated in
PubMed
PubMed ID
12403809
retrieved
31 January 2017
Takahiro Nobukuni
series ordinal
5
1 reference
stated in
PubMed
PubMed ID
12403809
retrieved
31 January 2017
Julian Sampson
series ordinal
7
1 reference
stated in
PubMed
PubMed ID
12403809
retrieved
31 January 2017
George Thomas
series ordinal
8
1 reference
stated in
PubMed
PubMed ID
12403809
retrieved
31 January 2017
Richard Lamb
series ordinal
9
1 reference
stated in
PubMed
PubMed ID
12403809
retrieved
31 January 2017
language of work or name
English
0 references
publication date
28 October 2002
1 reference
stated in
PubMed
PubMed ID
12403809
retrieved
31 January 2017
published in
Journal of Cell Biology
1 reference
stated in
PubMed
PubMed ID
12403809
retrieved
31 January 2017
volume
159
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stated in
PubMed
PubMed ID
12403809
retrieved
31 January 2017
page(s)
217–224
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PubMed
PubMed ID
12403809
retrieved
31 January 2017
issue
2
1 reference
stated in
PubMed
PubMed ID
12403809
retrieved
31 January 2017
cites work
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
17 March 2017
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
17 March 2017
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
17 March 2017
Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
17 March 2017
A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
17 March 2017
Oncogenic kinase signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
17 March 2017
Tuberin-dependent membrane localization of polycystin-1: a functional link between polycystic kidney disease and the TSC2 tumor suppressor gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
17 March 2017
The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
17 March 2017
Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
17 March 2017
Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
17 March 2017
Comprehensive mutation analysis of TSC1 and TSC2-and phenotypic correlations in 150 families with tuberous sclerosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
17 March 2017
Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
17 March 2017
Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
17 March 2017
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
17 March 2017
Phosphorylation and activation of p70s6k by PDK1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
17 March 2017
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
17 March 2017
Identification and characterization of the tuberous sclerosis gene on chromosome 16
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
17 March 2017
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
17 March 2017
Akt regulates growth by directly phosphorylating Tsc2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
7 April 2017
Regulation of translation initiation by FRAP/mTOR
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
7 April 2017
Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
7 April 2017
Mammalian TOR: a homeostatic ATP sensor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
29 September 2017
The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
29 September 2017
TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
29 September 2017
A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
29 September 2017
Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
29 September 2017
The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
29 September 2017
Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
29 September 2017
dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
27 November 2018
Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
27 November 2018
The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
27 November 2018
The genetic basis of tuberous sclerosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173059
retrieved
27 November 2018
Phosphatidylinositol 3-kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/12403809
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1083/JCB.JCB.200206108
1 reference
stated in
PubMed
PubMed ID
12403809
retrieved
31 January 2017
PMCID
2173059
0 references
PubMed ID
12403809
1 reference
stated in
PubMed
PubMed ID
12403809
retrieved
31 January 2017
ResearchGate publication ID
11059872
0 references
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