(Q39551585)

English

Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation

scientific article published on June 1999

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation (English)

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

phosphorylation

1 reference

based on heuristic

inferred from title

4

object named as

B A Hemmings

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

author name string

A Dufner

1

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

M Andjelkovic

2

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

B M Burgering

3

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

G Thomas

5

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

language of work or name

0 references

publication date

1 June 1999

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Molecular and Cellular Biology

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

19

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

6

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

4525-4534

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation

1 reference

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14 September 2017

The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

The akt kinase: molecular determinants of oncogenicity

1 reference

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14 September 2017

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

1 reference

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14 September 2017

Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

Translation control: connecting mitogens and the ribosome

1 reference

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14 September 2017

Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

Phosphorylation and activation of p70s6k by PDK1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

Role of translocation in the activation and function of protein kinase B

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

Phosphatidylinositol-3-OH kinase as a direct target of Ras

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104410

14 September 2017

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1 reference

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14 September 2017

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

1 reference

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14 September 2017

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1 reference

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Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1 reference

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Phosphorylation of the ribosomal protein S6 is elevated in cells transformed by a variety of tumor viruses

1 reference

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14 September 2017

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

1 reference

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14 September 2017

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1 reference

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14 September 2017

The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases

1 reference

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Characterization of the phosphoproteins and protein kinase activity in mTOR immunoprecipitates.

1 reference

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Phosphorylation sites in the autoinhibitory domain participate in p70(s6k) activation loop phosphorylation

1 reference

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Nuclear localization of p85s6k: functional requirement for entry into S phase.

1 reference

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25 September 2017

The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

1 reference

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25 September 2017

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

1 reference

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TOP genes: a translationally controlled class of genes including those coding for ribosomal proteins

1 reference

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25 September 2017

Activation of p70/p85 S6 kinase by a pathway independent of p21ras

1 reference

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25 September 2017

Control of p70 s6 kinase by kinase activity of FRAP in vivo

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Size control: cell proliferation does not equal growth

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Regulation of p70s6k/p85s6k and its role in the cell cycle

1 reference

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Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis

1 reference

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1 reference

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15 June 2018

Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites

1 reference

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Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

1 reference

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Construction and characterization of a conditionally active version of the serine/threonine kinase Akt.

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Retinoblastoma protein. Another role rolls in.

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p70s6k function is essential for G1 progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/10330191

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid-Regulated Kinases: Some Common Themes at Last

1 reference

https://pubmed.ncbi.nlm.nih.gov/10330191

12 December 2020

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The role of PI 3-kinase in insulin action

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.19.6.4525

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

release_bhxtuye3pfd7xlzagzccxxvjg4

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

ResearchGate publication ID

0 references

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