(Q58438150)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9838087%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

review article

1 reference

title

The role of PI 3-kinase in insulin action (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9838087%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9838087%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

author name string

C P Downes

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9838087%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

publication date

1 December 1998

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9838087%20AND%20SRC:MED&resulttype=core&format=json

Biochimica et Biophysica Acta

7 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9838087%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

volume

1436

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9838087%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

issue

1-2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9838087%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

page(s)

151-164

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9838087%20AND%20SRC:MED&resulttype=core&format=json

PDK1, one of the missing links in insulin signal transduction?

7 December 2019

cites work

1 reference

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Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system?

7 January 2021

1 reference

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Phosphoinositide 3-kinases: a conserved family of signal transducers

7 January 2021

1 reference

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Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Platelet-derived growth factor stimulates synthesis of PtdIns(3,4,5)P3 by activating a PtdIns(4,5)P2 3-OH kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Phosphatidylinositol 3,4,5-trisphosphate is formed from phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK Is generated by alternative splicing of the p85alpha gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Actin filaments participate in the relocalization of phosphatidylinositol3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Oncogenes and signal transduction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Regulation of phosphatidylinositol 3'-kinase by tyrosyl phosphoproteins. Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Phosphatidylinositol-3-OH kinase as a direct target of Ras

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Disruption of IRS-2 causes type 2 diabetes in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Two Naturally Occurring Insulin Receptor Tyrosine Kinase Domain Mutants Provide Evidence That Phosphoinositide 3-Kinase Activation Alone Is Not Sufficient for the Mediation of Insulin’s Metabolic and Mitogenic Effects

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Regulation of protein kinase B in rat adipocytes by insulin, vanadate, and peroxovanadate. Membrane translocation in response to peroxovanadate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Mechanism of activation of protein kinase B by insulin and IGF-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Role of translocation in the activation and function of protein kinase B

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

The modular phosphorylation and activation of p70s6k.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Phosphorylation and activation of p70s6k by PDK1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Construction and characterization of a conditionally active version of the serine/threonine kinase Akt.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Signaling pathway involved in the activation of heart 6-phosphofructo-2-kinase by insulin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Protein kinase B/Akt induces resumption of meiosis in Xenopus oocytes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

A constitutively active version of the Ser/Thr kinase Akt induces production of the ob gene product, leptin, in 3T3-L1 adipocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Phosphatidylinositol 3-kinase-gamma activates Bruton's tyrosine kinase in concert with Src family kinases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

The solution structure of the pleckstrin homology domain of mouse Son-of-sevenless 1 (mSos1)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from the GAP1IP4BP PH domain directing plasma membrane targeting.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Human rasGTPase-activating protein (human counterpart of GAP1m): sequence of the cDNA, primary structure of the protein, production and chromosomal localization.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Structure-function relationships of the mouse Gap1m. Determination of the inositol 1,3,4,5-tetrakisphosphate-binding domain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

Identification and cloning of centaurin-alpha. A novel phosphatidylinositol 3,4,5-trisphosphate-binding protein from rat brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900133-7

10.1016/S0005-2760(98)00133-7

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9838087%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

1 reference