(Q42796185)

English

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

scientific article published on July 1994

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scholarly article

1 reference

Europe PubMed Central

7 November 2017

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation (English)

1 reference

Europe PubMed Central

7 November 2017

0 references

1 reference

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6

object named as

C R Kahn

1 reference

Europe PubMed Central

7 November 2017

author name string

B Cheatham

1

1 reference

Europe PubMed Central

7 November 2017

C J Vlahos

2

1 reference

Europe PubMed Central

7 November 2017

L Cheatham

3

1 reference

Europe PubMed Central

7 November 2017

L Wang

4

1 reference

Europe PubMed Central

7 November 2017

J Blenis

5

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Europe PubMed Central

7 November 2017

language of work or name

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publication date

1 July 1994

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Europe PubMed Central

7 November 2017

Molecular and Cellular Biology

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Europe PubMed Central

7 November 2017

14

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Europe PubMed Central

7 November 2017

4902-4911

1 reference

Europe PubMed Central

7 November 2017

7

1 reference

Europe PubMed Central

7 November 2017

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling

1 reference

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27 May 2018

A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

An inositol tetrakisphosphate-containing phospholipid in activated neutrophils

1 reference

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27 May 2018

Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

The insulin receptor and the molecular mechanism of insulin action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

After insulin binds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Identification of Xenopus S6 protein kinase homologs (pp90rsk) in somatic cells: phosphorylation and activation during initiation of cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Insulin regulation of the two glucose transporters in 3T3-L1 adipocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

The novel inositol lipid phosphatidylinositol 3,4-bisphosphate is produced by human blood platelets upon thrombin stimulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Structural features of the colony-stimulating factor 1 receptor that affect its association with phosphatidylinositol 3-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Two types of phosphatidylinositol 3-kinase from bovine thymus. Monomer and heterodimer form

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Coordinate regulation of pp90rsk and a distinct protein-serine/threonine kinase activity that phosphorylates recombinant pp90rsk in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Molecular dissection of the secretory pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Distinct mechanisms for the activation of the RSK kinases/MAP2 kinase/pp90rsk and pp70-S6 kinase signaling systems are indicated by inhibition of protein synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Cysteine 647 in the insulin receptor is required for normal covalent interaction between alpha- and beta-subunits and signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

The insulin-sensitive glucose transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Transformation-defective mutants of polyomavirus middle T antigen associate with phosphatidylinositol 3-kinase (PI 3-kinase) but are unable to maintain wild-type levels of PI 3-kinase products in intact cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Phosphatidylinositol 3-kinase: a novel effector

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Interaction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

27 May 2018

Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=358862

16 August 2018

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8007986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An 81 kd protein complexed with middle T antigen and pp60c-src: a possible phosphatidylinositol kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/8007986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gelsolin-polyphosphoinositide interaction. Full expression of gelsolin-inhibiting function by polyphosphoinositides in vesicular form and inactivation by dilution, aggregation, or masking of the inositol head group

1 reference

https://pubmed.ncbi.nlm.nih.gov/8007986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-regulated glucose uptake in rat adipocytes is mediated by two transporter isoforms present in at least two vesicle populations

1 reference

https://pubmed.ncbi.nlm.nih.gov/8007986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polyphosphoinositides produced by phosphatidylinositol 3-kinase are poor substrates for phospholipases C from rat liver and bovine brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/8007986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is there a relationship between phosphatidylinositol trisphosphate and F-actin polymerization in human neutrophils?

1 reference

https://pubmed.ncbi.nlm.nih.gov/8007986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-stimulated phosphatidylinositol 3-kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density membrane vesicle

1 reference

https://pubmed.ncbi.nlm.nih.gov/8007986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/8007986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of IRS-1 with the insulin receptor and the phosphatidylinositol 3'-kinase. Formation of binary and ternary signaling complexes in intact cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8007986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p70s6k function is essential for G1 progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/8007986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

"Thrombin" receptor-directed ligand accounts for activation by thrombin of platelet phospholipase C and accumulation of 3-phosphorylated phosphoinositides

1 reference

https://pubmed.ncbi.nlm.nih.gov/8007986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8007986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transduction in neutrophil activation. Phosphatidylinositol 3-kinase is stimulated without tyrosine phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8007986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/8007986

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.14.7.4902

1 reference

Europe PubMed Central

7 November 2017

1 reference

Europe PubMed Central

7 November 2017

1 reference

Europe PubMed Central

7 November 2017

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