(Q67841197)

English

Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation

scientific article published on January 15, 1992

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Europe PubMed Central

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18 September 2019

Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation (English)

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18 September 2019

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10.1016/S0021-9258(18)48440-2

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30 November 2023

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30 November 2023

author name string

Myers MG Jr

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18 September 2019

J. M. Backer

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30 November 2023

G. G. Schroeder

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30 November 2023

C. R. Kahn

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30 November 2023

M. G. Myers

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30 November 2023

P. A. Wilden

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30 November 2023

D. A. Cahill

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30 November 2023

M. F. White

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1 January 1992

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18 September 2019

15 January 1992

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National Center for Biotechnology Information

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30 November 2023

full work available at URL

https://doi.org/10.1016/s0021-9258(18)48440-2

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30 November 2023

http://intl.jbc.org/cgi/content/abstract/267/2/1367

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30 November 2023

https://api.elsevier.com/content/article/PII:S0021925818484402?httpAccept=text/xml

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10.1016/S0021-9258(18)48440-2

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30 November 2023

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30 November 2023

Journal of Biological Chemistry

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18 September 2019

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18 September 2019

1367-1374

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18 September 2019

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18 September 2019

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

1

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10.1016/S0021-9258(18)48440-2

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30 November 2023

Cytoplasmic juxtamembrane region of the insulin receptor: a critical role in ATP binding, endogenous substrate phosphorylation, and insulin-stimulated bioeffects in CHO cells

3

1 reference

10.1016/S0021-9258(18)48440-2

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30 November 2023

Activated type I phosphatidylinositol kinase is associated with the epidermal growth factor (EGF) receptor following EGF stimulation

4

1 reference

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Oncogenes and signal transduction

5

1 reference

10.1016/S0021-9258(18)48440-2

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30 November 2023

Phosphoinositide kinases

7

1 reference

10.1016/S0021-9258(18)48440-2

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30 November 2023

Tyrosine phosphorylation is a signal for the trafficking of pp85, an 85-kDa phosphorylated polypeptide associated with phosphatidylinositol kinase activity

11

1 reference

10.1016/S0021-9258(18)48440-2

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30 November 2023

Role of phosphatidylinositol kinase in PDGF receptor signal transduction

12

1 reference

10.1016/S0021-9258(18)48440-2

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30 November 2023

An 81 kd protein complexed with middle T antigen and pp60c-src: a possible phosphatidylinositol kinase

13

1 reference

10.1016/S0021-9258(18)48440-2

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30 November 2023

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

16

1 reference

10.1016/S0021-9258(18)48440-2

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30 November 2023

The insulin receptor and the molecular mechanism of insulin action

19

1 reference

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30 November 2023

Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin

21

1 reference

10.1016/S0021-9258(18)48440-2

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30 November 2023

Phosphatidylinositol metabolism and polyoma-mediated transformation

22

1 reference

10.1016/S0021-9258(18)48440-2

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30 November 2023

Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

23

1 reference

10.1016/S0021-9258(18)48440-2

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30 November 2023

Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor

24

1 reference

10.1016/S0021-9258(18)48440-2

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30 November 2023

Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins

25

1 reference

10.1016/S0021-9258(18)48440-2

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30 November 2023

Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase

26

1 reference

10.1016/S0021-9258(18)48440-2

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30 November 2023

SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins

27

1 reference

10.1016/S0021-9258(18)48440-2

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30 November 2023

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

28

1 reference

10.1016/S0021-9258(18)48440-2

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30 November 2023

Recent insights in phosphatidylinositol signaling

32

1 reference

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30 November 2023

Analysis of insulin receptors on human lymphoblastoid cell lines by flow cytometry

33

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30 November 2023

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

36

1 reference

10.1016/S0021-9258(18)48440-2

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30 November 2023

Phosphorylation activates the insulin receptor tyrosine protein kinase

39

1 reference

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30 November 2023

A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol 3-kinase, or induction of c-fos and junB genes

41

1 reference

10.1016/S0021-9258(18)48440-2

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30 November 2023

Activation of phosphatidylinositol 3-kinase by insulin

42

1 reference

10.1016/S0021-9258(18)48440-2

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30 November 2023

Binding kinetics of mutated insulin receptors in transfected cells grown in suspension culture: application to the Tyr----Phe 960 insulin receptor mutant.

44

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Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

46

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Coding potential and regulatory signals of the polyoma virus genome

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Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils

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Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol

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Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

50

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Phosphorylation of middle T by pp60c-src: a switch for binding of phosphatidylinositol 3-kinase and optimal tumorigenesis

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Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

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Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

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The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase

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7 Preparation and use of anti-phosphotyrosine antibodies to study structure and function of insulin receptor

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Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

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Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

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The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth

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Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

59

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Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

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Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

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30 November 2023

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Europe PubMed Central

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18 September 2019

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