(Q28181376)

2

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Takahiro Nobukuni

3

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Manel Joaquin

4

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Marta Roccio

5

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Hugo Stocker

6

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Sara C Kozma

7

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Ernst Hafen

8

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Johannes L Bos

9

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George Thomas

Identification of TOR signaling complexes: more TORC for the cell growth engine

10

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language of work or name

English

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publication date

June 2003

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published in

Molecular Cell

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volume

11

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page(s)

1457-66

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issue

6

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cites work

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The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases

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Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

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A novel approach for expression cloning of small GTPases: identification, tissue distribution and chromosome mapping of the human homolog of rheb

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

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Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

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TOR, a central controller of cell growth

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Tuberous sclerosis complex

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Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity

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Stimulation of gene induction and cell growth by the Ras effector Rlf

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Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling

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