(Q40685477)

22 September 2017

title

Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration (English)

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22 September 2017

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Aristotelis Astrinidis

object named as

Aristotelis Astrinidis

1

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Jonathan Chernoff

object named as

Jonathan Chernoff

5

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author name string

Timothy P Cash

2

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22 September 2017

Deborah S Hunter

3

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22 September 2017

Cheryl L Walker

4

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22 September 2017

Elizabeth P Henske

6

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22 September 2017

language of work or name

English

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publication date

1 December 2002

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22 September 2017

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22 September 2017

volume

21

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22 September 2017

issue

55

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22 September 2017

page(s)

8470-8476

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The TSC1 gene product, hamartin, negatively regulates cell proliferation

22 September 2017

cites work

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

Chromosome 16 Loss of Heterozygosity in Tuberous Sclerosis and Sporadic Lymphangiomyomatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

Inactivation of the small GTPase Rho disrupts cellular attachment and induces adhesion-dependent and adhesion-independent apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

Current Protocols in Cell Biology

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

Genomic analysis of metastasis reveals an essential role for RhoC

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

Identification and characterization of the tuberous sclerosis gene on chromosome 16

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

Rho family proteins in cell adhesion and cell migration.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

Respiratory infections. An opportunity for integrated disease management

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

Tuberous sclerosis gene 2 product modulates transcription mediated by steroid hormone receptor family members

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

Phosphatidylinositol 3-kinase but not tuberin is required for PDGF-induced cell migration

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

Focal adhesion kinase and its potential involvement in tumor invasion and metastasis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

Rho GTPases: signaling, migration, and invasion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

FAK integrates growth-factor and integrin signals to promote cell migration

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

Y-27632, an inhibitor of Rho-associated kinases, prevents tyrosine phosphorylation of focal adhesion kinase and paxillin induced by bombesin: dissociation from tyrosine phosphorylation of p130(CAS).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

Lymphangioleiomyomatosis: a review

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

Expression of focal adhesion kinase gene and invasive cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

Allelic loss at the tuberous sclerosis 2 locus in spontaneous tumors in the Eker rat.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205962

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205962

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Dimensions Publication ID

22 September 2017

1004342868

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