(Q14877688)

identical protein binding

IEA

1 reference

14 February 2019

Disruption of the developmentally-regulated Col2a1 pre-mRNA alternative splicing switch in a transgenic knock-in mouse model

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

16 July 2018

Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

16 July 2018

Collagen XI chain misassembly in cartilage of the chondrodysplasia (cho) mouse

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

IDA

collagen type II trimer

4 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

16 July 2018

Disproportionate micromelia (Dmm): an incomplete dominant mouse dwarfism with abnormal cartilage matrix

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

16 July 2018

Expression and localization of collagen-binding stress protein Hsp47 in mouse embryo development: comparison with types I and II collagen

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

1 reference

14 February 2019

Age-dependent changes in the expression of matrix components in the mouse eye

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

4 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

16 July 2018

Protein consequences of the Col2a1 C-propeptide mutation in the chondrodysplastic Dmm mouse

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

16 July 2018

Chondrogenic differentiation during midfacial development in the mouse: in vivo and in vitro studies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Protein consequences of the Col2a1 C-propeptide mutation in the chondrodysplastic Dmm mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Chondrogenic differentiation during midfacial development in the mouse: in vivo and in vitro studies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

6 references

16 July 2018

Snorc is a novel cartilage specific small membrane proteoglycan expressed in differentiating and articular chondrocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

16 July 2018

Sox9 plays multiple roles in the lung epithelium during branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

16 July 2018

The transient expression of type II collagen at tissue interfaces during mammalian craniofacial development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

16 July 2018

Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

16 July 2018

Collagen XXVII organises the pericellular matrix in the growth plate

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

16 July 2018

Immunohistochemistry of collagen types II and X, and enzyme-histochemistry of alkaline phosphatase in the developing condylar cartilage of the fetal mouse mandible

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

collagen-containing extracellular matrix

IDA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Collagen XI chain misassembly in cartilage of the chondrodysplasia (cho) mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

collagen type II trimer

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Disproportionate micromelia (Dmm): an incomplete dominant mouse dwarfism with abnormal cartilage matrix

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Expression and localization of collagen-binding stress protein Hsp47 in mouse embryo development: comparison with types I and II collagen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Protein consequences of the Col2a1 C-propeptide mutation in the chondrodysplastic Dmm mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Chondrogenic differentiation during midfacial development in the mouse: in vivo and in vitro studies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

8 references

14 February 2019

Sox9 plays multiple roles in the lung epithelium during branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Snorc is a novel cartilage specific small membrane proteoglycan expressed in differentiating and articular chondrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Dentin sialophosphoprotein (DSPP) plays an essential role in the postnatal development and maintenance of mouse mandibular condylar cartilage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Immunohistochemistry of collagen types II and X, and enzyme-histochemistry of alkaline phosphatase in the developing condylar cartilage of the fetal mouse mandible

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

The transient expression of type II collagen at tissue interfaces during mammalian craniofacial development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Collagen XXVII organises the pericellular matrix in the growth plate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

cartilage development involved in endochondral bone morphogenesis

biological process

3 references

14 February 2019

The role of collagen II and cartilage fibril-associated molecules in skeletal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Skeletal development in transgenic mice expressing a mutation at Gly574Ser of type II collagen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Disproportionate micromelia (Dmm) in mice caused by a mutation in the C-propeptide coding region of Col2a1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

roof of mouth development

1 reference

14 February 2019

Disproportionate micromelia (Dmm): an incomplete dominant mouse dwarfism with abnormal cartilage matrix

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

1 reference

14 February 2019

Craniofacial and otic capsule abnormalities in a transgenic mouse strain with a Col2a1 mutation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

1 reference

14 February 2019

The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

chondrocyte differentiation

3 references

14 February 2019

The role of collagen II and cartilage fibril-associated molecules in skeletal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral bone

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

1 reference

14 February 2019

SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

collagen fibril organization

10 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

16 July 2018

Restoration of normal bone development by human homologue of collagen type II (COL2A1) gene in Col2a1 null mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

16 July 2018

Skeletal development in transgenic mice expressing a mutation at Gly574Ser of type II collagen

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

16 July 2018

Disproportionate micromelia (Dmm) in mice caused by a mutation in the C-propeptide coding region of Col2a1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

16 July 2018

Inactivation of one allele of the type II collagen gene alters the collagen network in murine articular cartilage and makes cartilage softer

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

16 July 2018

Collagen II is essential for the removal of the notochord and the formation of intervertebral discs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

16 July 2018

Histochemical, immunofluorescence, and ultrastructural differences in fetal cartilage among three genetically distinct chondrodystrophic mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

16 July 2018

Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral bone

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

16 July 2018

Disproportionate micromelia (Dmm): an incomplete dominant mouse dwarfism with abnormal cartilage matrix

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

skeletal system morphogenesis

IEA

4 references

14 February 2019

Pulmonary hypoplasia associated with reduced thoracic space in mice with disproportionate micromelia (DMM)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral bone

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Disproportionate micromelia (Dmm): an incomplete dominant mouse dwarfism with abnormal cartilage matrix

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Restoration of normal bone development by human homologue of collagen type II (COL2A1) gene in Col2a1 null mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

1 reference

14 February 2019

Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral bone

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

cellular response to BMP stimulus

1 reference

14 February 2019

Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFbeta signals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse

IDA

notochord development

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28481&geneProductId=UniProtKB:P28481

endochondral ossification

1 reference

14 February 2019

Craniofacial and otic capsule abnormalities in a transgenic mouse strain with a Col2a1 mutation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse

otic vesicle development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

central nervous system development

1 reference

14 February 2019

SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

Collagen II is essential for the removal of the notochord and the formation of intervertebral discs

cartilage development

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

The role of collagen II and cartilage fibril-associated molecules in skeletal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Craniofacial and otic capsule abnormalities in a transgenic mouse strain with a Col2a1 mutation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral bone

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Fine structure of extracellular matrix and basal laminae in two types of abnormal collagen production: L-proline analog-treated otocyst cultures and disproportionate micromelia (Dmm/Dmm) mutants

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Abnormal craniofacial growth and early mandibular osteoarthritis in mice harbouring a mutant type II collagen transgene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Inactivation of one allele of the type II collagen gene alters the collagen network in murine articular cartilage and makes cartilage softer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Disproportionate micromelia (Dmm): an incomplete dominant mouse dwarfism with abnormal cartilage matrix

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

proteoglycan metabolic process

Fine structure of extracellular matrix and basal laminae in two types of abnormal collagen production: L-proline analog-treated otocyst cultures and disproportionate micromelia (Dmm/Dmm) mutants

inner ear morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

1 reference

14 February 2019

More knee joint osteoarthritis (OA) in mice after inactivation of one allele of type II procollagen gene but less OA after lifelong voluntary wheel running exercise

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

regulation of gene expression

1 reference

14 February 2019

Apoptosis of chondrocytes in transgenic mice lacking collagen II

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

Craniofacial and otic capsule abnormalities in a transgenic mouse strain with a Col2a1 mutation

inner ear development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

1 reference

14 February 2019

Apoptosis of chondrocytes in transgenic mice lacking collagen II

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

1 reference

14 February 2019

Agenesis of the scapula in Emx2 homozygous mutants

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

Histochemical, immunofluorescence, and ultrastructural differences in fetal cartilage among three genetically distinct chondrodystrophic mice

cartilage condensation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

anterior head development

IEA

1 reference

14 February 2019

Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

skeletal system development

3 references

extracellular matrix organization

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

collagen fibril organization

11 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Collagen II is essential for the removal of the notochord and the formation of intervertebral discs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Inactivation of one allele of the type II collagen gene alters the collagen network in murine articular cartilage and makes cartilage softer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral bone

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Restoration of normal bone development by human homologue of collagen type II (COL2A1) gene in Col2a1 null mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Histochemical, immunofluorescence, and ultrastructural differences in fetal cartilage among three genetically distinct chondrodystrophic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Skeletal development in transgenic mice expressing a mutation at Gly574Ser of type II collagen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Disproportionate micromelia (Dmm): an incomplete dominant mouse dwarfism with abnormal cartilage matrix

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Disproportionate micromelia (Dmm) in mice caused by a mutation in the C-propeptide coding region of Col2a1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28481

Collagen triple helix repeat

has part(s)

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28481

VWFC domain

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28481

Fibrillar collagen, C-terminal

1 reference

stated in

InterPro Release 71.0