(Q14878305)

English

Interleukin 13

mammalian protein found in Mus musculus

Il13
T-cell activation protein P600
interleukin-13

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20109

four-helical cytokine-like, core

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20109

Interleukin-4/interleukin-13, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

cytokine receptor binding

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

cytokine activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

interleukin-13 receptor binding

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

protein binding

determination method

1 reference

9 May 2019

IL-13Rα2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

determination method

1 reference

9 May 2019

Localization of pro-inflammatory (IL-12, IL-15) and anti-inflammatory (IL-11, IL-13) cytokines at the foetomaternal interface during murine pregnancy

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

extracellular region

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

extracellular space

determination method

9 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

9 May 2019

The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

9 May 2019

IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

9 May 2019

Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

9 May 2019

GATA-3 regulates the development and function of invariant NKT cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

9 May 2019

Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

9 May 2019

CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

9 May 2019

Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

biological process

positive regulation of macrophage activation

determination method

1 reference

9 May 2019

IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

cellular response to cytokine stimulus

determination method

1 reference

9 May 2019

IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

immune response

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

inflammatory response

determination method

1 reference

9 May 2019

Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

regulation of signaling receptor activity

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

microglial cell activation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

positive regulation of immunoglobulin production

determination method

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

9 May 2019

IgE generation and mast cell effector function in mice deficient in IL-4 and IL-13

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

9 May 2019

IgE generation and mast cell effector function in mice deficient in IL-4 and IL-13

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

regulation of proton transport

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

positive regulation of B cell proliferation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

positive regulation of connective tissue growth factor production

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

negative regulation of NAD(P)H oxidase activity

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

response to nicotine

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

positive regulation of tyrosine phosphorylation of STAT protein

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

positive regulation of ion transport

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

positive regulation of smooth muscle cell proliferation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

positive regulation of protein secretion

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

positive regulation of release of sequestered calcium ion into cytosol

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

negative regulation of transforming growth factor beta production

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

negative regulation of neuron death

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

positive regulation of pancreatic stellate cell proliferation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

positive regulation of cold-induced thermogenesis

determination method

1 reference

9 May 2019

Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

signal transduction

determination method

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20109

determination method

Interleukin-4/interleukin-13, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20109

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000020650

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000020650

Sitelinks

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