(Q14889534)

English

Interleukin 7

mammalian protein found in Mus musculus

Il7
uniprot:P10168
interleukin-7

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10168

Interleukin-7 superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10168

Interleukin-7/Interleukin-9, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

growth factor activity

determination method

3 references

cytokine receptor binding

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10168

determination method

interleukin-7 receptor binding

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10168

determination method

cytokine activity

determination method

5 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10168

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10168

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10168

determination method

14 February 2019

Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10168

determination method

14 February 2019

IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor kappa B ligand and tumor necrosis factor alpha from T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10168

determination method

extracellular region

determination method

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10168

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10168

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10168

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10168

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10168

determination method

biological process

regulation of gene expression

determination method

positive regulation of T cell differentiation

determination method

1 reference

14 February 2019

Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10168

determination method

homeostasis of number of cells within a tissue

determination method

1 reference

14 February 2019

The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10168

determination method

negative regulation of extrinsic apoptotic signaling pathway

determination method

1 reference

14 February 2019

Several different cell surface molecules control negative selection of medullary thymocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10168

determination method

positive regulation of organ growth

determination method

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

determination method

1 reference

14 February 2019

Interleukin-7 inhibits apoptosis of mouse malignant T-lymphoma cells by both suppressing the CPP32-like protease activation and inducing the Bcl-2 expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10168

determination method

negative regulation of catalytic activity

determination method

1 reference

14 February 2019

Interleukin-7 inhibits apoptosis of mouse malignant T-lymphoma cells by both suppressing the CPP32-like protease activation and inducing the Bcl-2 expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10168

determination method

bone resorption

determination method

1 reference

14 February 2019

IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor kappa B ligand and tumor necrosis factor alpha from T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10168

determination method

T cell lineage commitment

determination method

1 reference

14 February 2019

The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10168

determination method

immune response

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10168

determination method

regulation of signaling receptor activity

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10168

determination method

regulation of peptidyl-tyrosine phosphorylation

determination method

1 reference

14 February 2019

IL-7-induced phosphorylation of the adaptor Crk-like and other targets.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10168

determination method

positive regulation of gene expression

determination method

1 reference

14 February 2019

Interleukin-7 partially rescues B-lymphopoiesis in osteopetrotic oc/oc mice through the engagement of B220+ CD11b+ progenitors.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10168

determination method

positive regulation of B cell differentiation

determination method

1 reference

14 February 2019

Interleukin-7 partially rescues B-lymphopoiesis in osteopetrotic oc/oc mice through the engagement of B220+ CD11b+ progenitors.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10168

determination method

Interleukin-7/Interleukin-9, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10168

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000141845

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000141845

ENSMUSP00000126219

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000126219

ENSMUSP00000141508

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000141508

ENSMUSP00000141827

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000141827

Sitelinks

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Multilingual sites(0 entries)

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