(Q14901460)

Protein kinase-like domain superfamily

1 reference

tyrosine-protein kinase, insulin-like receptor

1 reference

Fibronectin type III superfamily

1 reference

Growth factor receptor cysteine-rich domain superfamily

1 reference

Receptor L-domain superfamily

1 reference

membrane proteins

1 reference

inferred from GOA cell component → membrane

Fibronectin type III, protein family

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

Receptor L-domain, protein family

1 reference

Furin-like cysteine-rich domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, receptor class II, conserved site, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

Furin-like repeat, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

protein kinase activity

1 reference

14 February 2019

insulin receptor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

insulin-like growth factor I binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

phosphatidylinositol 3-kinase binding

3 references

2 references

identical protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

insulin receptor substrate binding

protein tyrosine kinase activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

2 references

insulin-like growth factor binding

ISS

G-protein alpha-subunit binding

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

transmembrane receptor protein tyrosine kinase activity

insulin-activated receptor activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

insulin receptor substrate binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

integral component of membrane

cell component

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

14 February 2019

Decreased insulin-like growth factor I-mediated protein tyrosine phosphorylation in human olivopontocerebellar atrophy and lurcher mutant mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

3 references

intracellular membrane-bounded organelle

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

1 reference

24 April 2018

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60751&geneProductId=UniProtKB:Q60751

alphav-beta3 integrin-IGF-1-IGF1R complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

14 February 2019

Conditional deletion of insulin-like growth factor-I receptor in prostate epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

14 February 2019

Lack of myotubularin (MTM1) leads to muscle hypotrophy through unbalanced regulation of the autophagy and ubiquitin-proteasome pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60751&geneProductId=UniProtKB:Q60751

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

integral component of plasma membrane

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

insulin receptor complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

exocrine pancreas development

biological process

1 reference

14 February 2019

Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

insulin-like growth factor receptor signaling pathway

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60751&geneProductId=UniProtKB:Q60751

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60751&geneProductId=UniProtKB:Q60751

24 April 2018

Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60751&geneProductId=UniProtKB:Q60751

negative regulation of protein kinase B signaling

IC

1 reference

14 February 2019

Conditional deletion of insulin-like growth factor-I receptor in prostate epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

positive regulation of protein kinase B signaling

1 reference

24 April 2018

Conditional deletion of insulin-like growth factor-I receptor in prostate epithelium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60751&geneProductId=UniProtKB:Q60751

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

transmembrane receptor protein tyrosine kinase signaling pathway

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60751&geneProductId=UniProtKB:Q60751

positive regulation of cell migration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

negative regulation of apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

adrenal gland development

1 reference

14 February 2019

Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

Testis determination requires insulin receptor family function in mice

IGI

male sex determination

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

protein tetramerization

ISS

negative regulation of DNA-binding transcription factor activity

2 references

1 reference

14 February 2019

Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

mammary gland development

1 reference

14 February 2019

Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

positive regulation of transcription, DNA-templated

1 reference

14 February 2019

Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

1 reference

14 February 2019

Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

regulation of JNK cascade

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60751&geneProductId=UniProtKB:Q60751

prostate gland epithelium morphogenesis

1 reference

14 February 2019

Conditional deletion of insulin-like growth factor-I receptor in prostate epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

negative regulation of MAPK cascade

1 reference

14 February 2019

Conditional deletion of insulin-like growth factor-I receptor in prostate epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition

epidermis development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

cellular response to insulin stimulus

1 reference

14 February 2019

The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

animal organ morphogenesis

1 reference

14 February 2019

Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

peptidyl-tyrosine autophosphorylation

IDA

protein autophosphorylation

3 references

positive regulation of mitotic nuclear division

1 reference

14 February 2019

Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

phosphatidylinositol-mediated signaling

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

cellular response to glucose stimulus

1 reference

24 April 2018

The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60751&geneProductId=UniProtKB:Q60751

positive regulation of MAPK cascade

1 reference

24 April 2018

Conditional deletion of insulin-like growth factor-I receptor in prostate epithelium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60751&geneProductId=UniProtKB:Q60751

positive regulation of meiotic cell cycle

1 reference

14 February 2019

Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

IGI

amyloid-beta clearance

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

cellular response to amyloid-beta

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

positive regulation of cell population proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

insulin receptor signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

negative regulation of muscle cell apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

positive regulation of phosphatidylinositol 3-kinase signaling

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60751&geneProductId=UniProtKB:Q60751

cerebellum development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

establishment of cell polarity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

neuron projection development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

positive regulation of cytokinesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

positive regulation of osteoblast proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

positive regulation of protein-containing complex disassembly

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

positive regulation of smooth muscle cell proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

positive regulation of axon regeneration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

positive regulation of DNA metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

protein heterooligomerization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

cellular response to transforming growth factor beta stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

positive regulation of steroid hormone biosynthetic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

dendritic spine maintenance

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

response to L-glutamate

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

negative regulation of hepatocyte apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

negative regulation of cholangiocyte apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

cellular response to angiotensin

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

cellular response to insulin-like growth factor stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

insulin-like growth factor receptor signaling pathway

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

14 February 2019

Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

anatomical structure development

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

cellular response to glucose stimulus

positive regulation of cold-induced thermogenesis

1 reference

14 February 2019

Essential Role of IGFIR in the Onset of Male Brown Fat Thermogenic Function: Regulation of Glucose Homeostasis by Differential Organ-Specific Insulin Sensitivity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60751

1 reference

Furin-like repeat

1 reference

tyrosine-protein kinase, active site

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

Receptor L-domain

1 reference

protein kinase, ATP binding site

1 reference

tyrosine-protein kinase, receptor class II, conserved site

1 reference

Furin-like cysteine-rich domain

1 reference

protein kinase domain

1 reference