(Q14902507)

English

Aquaporin 4

mammalian protein found in Mus musculus

MIWC
WCH4
aquaporin-4
mercurial-insensitive water channel
Aqp4

In more languages

Statements

1 reference

12 September 2018

UniProt protein ID

0 references

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55088

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55088

Major intrinsic protein, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

12 September 2018

UniProt protein ID

1 reference

12 September 2018

UniProt protein ID

molecular function

protein binding

determination method

1 reference

9 May 2019

An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

identical protein binding

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

channel activity

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

water channel activity

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

Gene structure, cDNA cloning, and expression of a mouse mercurial-insensitive water channel

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

Identification of a molecular target for glutamate regulation of astrocyte water permeability.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

plasma membrane

determination method

3 references

10 September 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55088&geneProductId=UniProtKB:P55088

determination method

10 September 2018

Expression and localisation of aquaporin water channels in human urothelium in situ and in vitro

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55088&geneProductId=UniProtKB:P55088

determination method

10 September 2018

Cardiac aquaporin expression in humans, rats, and mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55088&geneProductId=UniProtKB:P55088

determination method

external side of plasma membrane

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

basal plasma membrane

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

basolateral plasma membrane

determination method

5 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55088&geneProductId=UniProtKB:P55088

determination method

24 April 2018

Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55088&geneProductId=UniProtKB:P55088

determination method

24 April 2018

Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55088&geneProductId=UniProtKB:P55088

determination method

24 April 2018

Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55088&geneProductId=UniProtKB:P55088

determination method

24 April 2018

Vasopressin-dependent coupling between sodium transport and water flow in a mouse cortical collecting duct cell line

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55088&geneProductId=UniProtKB:P55088

determination method

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

cell projection membrane

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

protein-containing complex

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

basolateral plasma membrane

determination method

7 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

8 April 2019

Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

8 April 2019

Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

8 April 2019

Vasopressin-dependent coupling between sodium transport and water flow in a mouse cortical collecting duct cell line

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

8 April 2019

Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

8 April 2019

Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

plasma membrane

determination method

4 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

8 April 2019

Expression and localisation of aquaporin water channels in human urothelium in situ and in vitro

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

8 April 2019

Cardiac aquaporin expression in humans, rats, and mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

integral component of membrane

determination method

3 references

9 May 2019

Gene structure, cDNA cloning, and expression of a mouse mercurial-insensitive water channel

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

integral component of plasma membrane

determination method

3 references

9 May 2019

mRNAs encoding aquaporins are present during murine preimplantation development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

Identification of a molecular target for glutamate regulation of astrocyte water permeability.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

astrocyte end-foot

determination method

1 reference

8 April 2019

A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

extracellular region

determination method

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

plasma membrane

determination method

5 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

Expression and localisation of aquaporin water channels in human urothelium in situ and in vitro

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

Cardiac aquaporin expression in humans, rats, and mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

endosome membrane

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

basolateral plasma membrane

determination method

8 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

Vasopressin-dependent coupling between sodium transport and water flow in a mouse cortical collecting duct cell line

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

determination method

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

Supramolecular aggregation of aquaporin-4 is different in muscle and brain: correlation with tissue susceptibility in neuromyelitis optica.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

cell projection

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

biological process

sensory perception of sound

determination method

1 reference

9 May 2019

Impaired hearing in mice lacking aquaporin-4 water channels

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

ion transmembrane transport

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55088&geneProductId=UniProtKB:P55088

determination method

cellular response to interferon-gamma

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

renal water absorption

determination method

3 references

9 May 2019

Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

transmembrane transport

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

water transport

determination method

3 references

14 February 2019

mRNAs encoding aquaporins are present during murine preimplantation development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

14 February 2019

Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

regulation of vascular endothelial growth factor production

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

carbon dioxide transport

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

negative regulation of interleukin-1 beta production

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

negative regulation of interleukin-6 production

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

protein homooligomerization

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

negative regulation of cell adhesion molecule production

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

cellular response to glucose stimulus

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

water transport

determination method

4 references

9 May 2019

mRNAs encoding aquaporins are present during murine preimplantation development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

Identification of a molecular target for glutamate regulation of astrocyte water permeability.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

cellular water homeostasis

determination method

1 reference

9 May 2019

Identification of a molecular target for glutamate regulation of astrocyte water permeability.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

water homeostasis

determination method

3 references

9 May 2019

Gene structure, cDNA cloning, and expression of a mouse mercurial-insensitive water channel

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

Aquaporin deletion in mice reduces intraocular pressure and aqueous fluid production

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

9 May 2019

Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

protein homotetramerization

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

cerebrospinal fluid circulation

determination method

1 reference

9 May 2019

A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

cell-cell adhesion

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55088

determination method

Major intrinsic protein, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55088

Identifiers

RefSeq protein ID

1 reference

14 September 2018

1 reference

14 September 2018

1 reference

14 September 2018

1 reference

14 September 2018

1 reference

14 September 2018

1 reference

14 September 2018

1 reference

14 September 2018

1 reference

14 September 2018

1 reference

14 September 2018

UniProt protein ID

1 reference

12 September 2018

UniProt protein ID

Ensembl protein ID

ENSMUSP00000078088

1 reference

ensembl Release 94

Ensembl protein ID

ENSMUSP00000078088

ScienceDirect topic ID

agricultural-and-biological-sciences/aquaporin-4

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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