(Q14904572)

English

Neurotrophin 3

mammalian protein found in Mus musculus

neurotrophic factor
NGF-2
neurotrophin-3
HDNF
Ntf3
nerve growth factor 2

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Cystine-knot cytokine

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20181

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20181

Nerve growth factor-related, protein family

1 reference

based on heuristic

inferred from protein domain or family

Nerve growth factor conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

neurotrophin p75 receptor binding

determination method

1 reference

14 February 2019

Spatiotemporal patterns of expression of neurotrophins and neurotrophin receptors in mice suggest functional roles in testicular and epididymal morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

neurotrophin receptor binding

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

signaling receptor binding

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

growth factor activity

determination method

3 references

chemoattractant activity

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

nerve growth factor binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

endoplasmic reticulum lumen

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

extracellular region

determination method

cytoplasmic vesicle

determination method

1 reference

24 April 2018

The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20181&geneProductId=UniProtKB:P20181

determination method

extracellular region

determination method

2 references

extracellular space

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

synaptic vesicle

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

biological process

negative regulation of neuron apoptotic process

determination method

1 reference

24 April 2018

Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20181&geneProductId=UniProtKB:P20181

determination method

regulation of neuron differentiation

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

glial cell fate determination

determination method

1 reference

14 February 2019

Mice lacking NT-3, and its receptor TrkC, exhibit profound deficiencies in CNS glial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

peripheral nervous system development

determination method

regulation of neuron apoptotic process

determination method

1 reference

14 February 2019

The novel neurotrophin-regulated neuronal development-associated protein, NDAP, mediates apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

neuron development

determination method

1 reference

14 February 2019

Most classes of dorsal root ganglion neurons are severely depleted but not absent in mice lacking neurotrophin-3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

smooth muscle cell differentiation

determination method

1 reference

14 February 2019

Evidence for the involvement of neurotrophins in muscle transdifferentiation and acetylcholine receptor transformation in the esophagus of Myf5(-/-):MyoD(-/-) and NT-3(-/-) embryos

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

mechanoreceptor differentiation

determination method

1 reference

14 February 2019

Pacinian corpuscle development involves multiple Trk signaling pathways

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

generation of neurons

determination method

1 reference

14 February 2019

Genetic evidence for selective neurotrophin 3 signalling through TrkC but not TrkB in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

enteric nervous system development

determination method

1 reference

14 February 2019

Evidence for the involvement of neurotrophins in muscle transdifferentiation and acetylcholine receptor transformation in the esophagus of Myf5(-/-):MyoD(-/-) and NT-3(-/-) embryos

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

neuromuscular synaptic transmission

determination method

1 reference

14 February 2019

Muscle spindle-derived neurotrophin 3 regulates synaptic connectivity between muscle sensory and motor neurons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

brain development

determination method

1 reference

14 February 2019

Neurotrophin-3 is required for proper cerebellar development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

epidermis development

determination method

1 reference

14 February 2019

A new role for neurotrophin-3: involvement in the regulation of hair follicle regression (catagen)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

nerve development

determination method

1 reference

24 April 2018

Complementary roles of BDNF and NT-3 in vestibular and auditory development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20181&geneProductId=UniProtKB:P20181

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

14 February 2019

Peripheral NT3 signaling is required for ETS protein expression and central patterning of proprioceptive sensory afferents

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

determination method

3 references

14 February 2019

A chemoattractant role for NT-3 in proprioceptive axon guidance

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

14 February 2019

NGF, BDNF and NT-3 play unique roles in the in vitro development and patterning of innervation of the mammalian inner ear

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

14 February 2019

A chemoattractant role for NT-3 in proprioceptive axon guidance

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

positive chemotaxis

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

regulation of signaling receptor activity

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

positive regulation of receptor internalization

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

nervous system development

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

positive regulation of cell population proliferation

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

positive regulation of cell migration

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

activation of protein kinase B activity

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

positive regulation of peptidyl-serine phosphorylation

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

regulation of apoptotic process

determination method

1 reference

14 February 2019

Dok5 is involved in the signaling pathway of neurotrophin-3 against TrkC-induced apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

positive regulation of glial cell differentiation

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

positive regulation of peptidyl-tyrosine phosphorylation

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

negative regulation of peptidyl-tyrosine phosphorylation

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

modulation of chemical synaptic transmission

determination method

1 reference

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20181&geneProductId=UniProtKB:P20181

determination method

induction of positive chemotaxis

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

activation of GTPase activity

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

positive regulation of actin cytoskeleton reorganization

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

peripheral nervous system development

determination method

3 references

14 February 2019

A local action of neurotrophin-3 prevents the death of proliferating sensory neuron precursor cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

14 February 2019

Peripheral NT3 signaling is required for ETS protein expression and central patterning of proprioceptive sensory afferents

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

nerve growth factor signaling pathway

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

neuron projection morphogenesis

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20181

determination method

Nerve growth factor conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20181

Nerve growth factor-related

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20181

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000052302

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000052302

ENSMUSP00000107863

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000107863

ENSMUSP00000144828

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000144828

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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