(Q14905246)

http://www.ebi.ac.uk/interpro/protein/Q02013

Aquaporin-like

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02013

Major intrinsic protein, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

potassium ion transmembrane transporter activity

1 reference

14 February 2019

Homeostatic maintenance of pathogen-containing vacuoles requires TBK1-dependent regulation of aquaporin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

mRNAs encoding aquaporins are present during murine preimplantation development

water channel activity

4 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02013&geneProductId=UniProtKB:Q02013

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02013&geneProductId=UniProtKB:Q02013

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02013&geneProductId=UniProtKB:Q02013

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02013&geneProductId=UniProtKB:Q02013

EphB2 guides axons at the midline and is necessary for normal vestibular function

ephrin receptor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

glycerol transmembrane transporter activity

IPI

potassium channel activity

ammonium transmembrane transporter activity

2 references

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

transmembrane transporter activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

carbon dioxide transmembrane transporter activity

3 references

identical protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

glycerol transmembrane transporter activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

mRNAs encoding aquaporins are present during murine preimplantation development

water channel activity

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Identification and characterization of an aquaporin 1 immunoreactive amacrine-type cell of the mouse retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Aquaporin 1 is important for maintaining secretory granule biogenesis in endocrine cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

apical plasma membrane

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Aquaporin-1 in the choroid plexuses of developing mammalian brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Very high aquaporin-1 facilitated water permeability in mouse gallbladder

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Aquaporin-1 in cardiac endothelial cells is downregulated in ischemia, hypoxia and cardioplegia

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

dense core granule membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

1 reference

14 February 2019

Anatomical and functional analysis of aquaporin 1, a water channel in primary afferent neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

3 references

symbiont-containing vacuole

1 reference

14 February 2019

Homeostatic maintenance of pathogen-containing vacuoles requires TBK1-dependent regulation of aquaporin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

integral component of plasma membrane

1 reference

14 February 2019

mRNAs encoding aquaporins are present during murine preimplantation development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

basolateral plasma membrane

TAS

3 references

1 reference

14 February 2019

Aquaporin-1 in cardiac endothelial cells is downregulated in ischemia, hypoxia and cardioplegia

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

2 references

2 references

basal plasma membrane

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Aquaporin-1 in cardiac endothelial cells is downregulated in ischemia, hypoxia and cardioplegia

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

symbiont-containing vacuole membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

brush border membrane

2 references

2 references

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

9 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Aquaporin deletion in mice reduces corneal water permeability and delays restoration of transparency after swelling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Anatomical and functional analysis of aquaporin 1, a water channel in primary afferent neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Analysis of double knockout mice lacking aquaporin-1 and urea transporter UT-B. Evidence for UT-B-facilitated water transport in erythrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Aquaporin-1 plays an essential role in water permeability and ultrafiltration during peritoneal dialysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Role of aquaporin water channels in pleural fluid dynamics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Functional expression of aquaporins in embryonic, postnatal, and adult mouse lenses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

basolateral plasma membrane

4 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02013&geneProductId=UniProtKB:Q02013

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02013&geneProductId=UniProtKB:Q02013

10 September 2018

Aquaporin-1 in the choroid plexuses of developing mammalian brain

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02013&geneProductId=UniProtKB:Q02013

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02013&geneProductId=UniProtKB:Q02013

integral component of membrane

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Unimpaired osmotic water permeability and fluid secretion in bile duct epithelia of AQP1 null mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

Aquaporin 1 is important for maintaining secretory granule biogenesis in endocrine cells

biological process

corticotropin secretion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

metanephric descending thin limb development

1 reference

14 February 2019

Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

3 references

16 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Phenotype analysis of aquaporin-8 null mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Role of aquaporin and sodium channel in pleural water movement

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Reduced osmotic water permeability of the peritoneal barrier in aquaporin-1 knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Aquaporin-1 plays an essential role in water permeability and ultrafiltration during peritoneal dialysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Effect of aquaporin-1 deletion on pleural fluid transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Role of aquaporin water channels in pleural fluid dynamics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Luminal hypotonicity in proximal tubules of aquaporin-1-knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Accelerated cataract formation and reduced lens epithelial water permeability in aquaporin-1-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Requirement of aquaporin-1 for NaCl-driven water transport across descending vasa recta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Analysis of double knockout mice lacking aquaporin-1 and urea transporter UT-B. Evidence for UT-B-facilitated water transport in erythrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

hyperosmotic salinity response

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

Compensation of proximal tubule malabsorption in AQP1-deficient mice without TGF-mediated reduction of GFR

glomerular filtration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

metanephric proximal convoluted tubule segment 2 development

1 reference

14 February 2019

Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

1 reference

14 February 2019

Aquaporin-1-facilitated keratocyte migration in cell culture and in vivo corneal wound healing models

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

hyperosmotic response

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02013&geneProductId=UniProtKB:Q02013

1 reference

14 February 2019

Aquaporin deletion in mice reduces intraocular pressure and aqueous fluid production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

metanephric proximal straight tubule development

1 reference

14 February 2019

Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

sensory perception of pain

1 reference

14 February 2019

Impaired pain sensation in mice lacking Aquaporin-1 water channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

Urea and urine concentrating ability in mice lacking AQP1 and AQP3

renal water absorption

11 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Analysis of double knockout mice lacking aquaporin-1 and urea transporter UT-B. Evidence for UT-B-facilitated water transport in erythrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Partial correction of the urinary concentrating defect in aquaporin-1 null mice by adenovirus-mediated gene delivery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

14 February 2019

Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

secretory granule organization

IGI

1 reference

14 February 2019

Aquaporin 1 is important for maintaining secretory granule biogenesis in endocrine cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

metanephric glomerulus vasculature development

1 reference

14 February 2019

Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

1 reference

14 February 2019

Defective dietary fat processing in transgenic mice lacking aquaporin-1 water channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

1 reference

14 February 2019

Aquaporin 1 is important for maintaining secretory granule biogenesis in endocrine cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

positive regulation of cell migration

1 reference

14 February 2019

Aquaporin-1-facilitated keratocyte migration in cell culture and in vivo corneal wound healing models

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

Homeostatic maintenance of pathogen-containing vacuoles requires TBK1-dependent regulation of aquaporin-1

potassium ion transport

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

camera-type eye morphogenesis

1 reference

14 February 2019

Aquaporin deletion in mice reduces corneal water permeability and delays restoration of transparency after swelling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

ammonium transmembrane transport

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02013&geneProductId=UniProtKB:Q02013

potassium ion transmembrane transport

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

renal water transport

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02013&geneProductId=UniProtKB:Q02013

cell volume homeostasis

2 references

carbon dioxide transport

2 references

2 references

nitric oxide transport

2 references

cellular response to UV

transepithelial water transport

2 references

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

transmembrane transport

1 reference

14 February 2019

cellular response to copper ion

cellular response to mercury ion

2 references

cellular response to cAMP

2 references

cellular response to hypoxia

2 references

cellular response to salt stress

2 references

cellular hyperosmotic response

2 references

cellular response to nitric oxide

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

cGMP biosynthetic process

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02013&geneProductId=UniProtKB:Q02013

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02013&geneProductId=UniProtKB:Q02013

cGMP-mediated signaling

1 reference

21 June 2018

cGMP-mediated signaling

ion transmembrane transport

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

carbon dioxide transmembrane transport

3 references

ammonium transmembrane transport

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

cation transmembrane transport

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02013

Major intrinsic protein, conserved site

has part(s)

1 reference

stated in

InterPro Release 71.0