(Q14906506)

Helix-loop-helix DNA-binding domain superfamily

1 reference

MiT/TFE transcription factors, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

MiT/TFE transcription factors, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

0 references

1 reference

25 May 2022

1 reference

25 May 2022

sequence-specific DNA binding

ISA

1 reference

14 February 2019

Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

DNA-binding transcription factor activity

ISA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

3 references

14 February 2019

14 February 2019

Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

Transcriptional activation of mouse mast cell protease-9 by microphthalmia-associated transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

chromatin binding

1 reference

14 February 2019

Pax3 functions at a nodal point in melanocyte stem cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

1 reference

10 September 2018

Pax3 functions at a nodal point in melanocyte stem cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08874&geneProductId=UniProtKB:Q08874

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

10 September 2018

Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITF

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08874&geneProductId=UniProtKB:Q08874

RNA polymerase II cis-regulatory region sequence-specific DNA binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

DNA-binding transcription activator activity, RNA polymerase II-specific

6 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08874&geneProductId=UniProtKB:Q08874

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08874&geneProductId=UniProtKB:Q08874

10 September 2018

Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08874&geneProductId=UniProtKB:Q08874

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

E-box binding

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

protein binding

IPI

1 reference

14 February 2019

Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

DNA-binding transcription factor activity, RNA polymerase II-specific

IPI

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

Transcriptional activation of mouse mast cell protease-9 by microphthalmia-associated transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

IC

biological process

cell differentiation

1 reference

14 February 2019

Melanocyte development in vivo and in neural crest cell cultures: crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

cell fate commitment

1 reference

14 February 2019

Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

osteoclast differentiation

1 reference

14 February 2019

Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

negative regulation of apoptotic process

1 reference

14 February 2019

Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

Wnt signaling pathway

1 reference

14 February 2019

Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

canonical Wnt signaling pathway involved in negative regulation of apoptotic process

1 reference

14 February 2019

Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

1 reference

14 February 2019

regulation of cell population proliferation

1 reference

14 February 2019

Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

bone remodeling

1 reference

14 February 2019

Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

regulation of gene expression

1 reference

14 February 2019

Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

camera-type eye development

1 reference

14 February 2019

Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

transcription by RNA polymerase II

1 reference

16 July 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08874&geneProductId=UniProtKB:Q08874

regulation of transcription, DNA-templated

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

melanocyte differentiation

Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08874&geneProductId=UniProtKB:Q08874

16 July 2018

Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08874&geneProductId=UniProtKB:Q08874

16 July 2018

Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08874&geneProductId=UniProtKB:Q08874

pigmentation

Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

regulation of osteoclast differentiation

Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

positive regulation of transcription, DNA-templated

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

Transcriptional activation of mouse mast cell protease-9 by microphthalmia-associated transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

positive regulation of transcription by RNA polymerase II

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

ISO

14 February 2019

Pax3 functions at a nodal point in melanocyte stem cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

negative regulation of cell migration

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08874&geneProductId=UniProtKB:Q08874

melanocyte differentiation

Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08874

MiT/TFE transcription factors, N-terminal

IBA

has part(s)

1 reference

Myc-type, basic helix-loop-helix (bHLH) domain

1 reference

MiT/TFE transcription factors, C-terminal

1 reference