(Q14907100)

English

Lysyl oxidase

mammalian protein found in Mus musculus

protein-lysine 6-oxidase
ras excision protein
ras recision
Lox

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28301

Lysyl oxidase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

metal ion binding

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

protein binding

determination method

4 references

14 February 2019

Lysyl oxidase binds transforming growth factor-beta and regulates its signaling via amine oxidase activity.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Fibulin-4 conducts proper elastogenesis via interaction with cross-linking enzyme lysyl oxidase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

oxidoreductase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

protein-lysine 6-oxidase activity

determination method

7 references

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28301&geneProductId=UniProtKB:P28301

determination method

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28301&geneProductId=UniProtKB:P28301

determination method

26 September 2017

Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28301&geneProductId=UniProtKB:P28301

determination method

26 September 2017

Lysyl oxidase deficiency in lung and fibroblasts from mice with hereditary emphysema

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28301&geneProductId=UniProtKB:P28301

determination method

26 September 2017

Up-regulation and altered distribution of lysyl oxidase in the central nervous system of mutant SOD1 transgenic mouse model of amyotrophic lateral sclerosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28301&geneProductId=UniProtKB:P28301

determination method

26 September 2017

Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28301&geneProductId=UniProtKB:P28301

determination method

26 September 2017

Decreased lysyl oxidase activity in the aneurysm-prone, mottled mouse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28301&geneProductId=UniProtKB:P28301

determination method

protein-lysine 6-oxidase activity

determination method

9 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Up-regulation and altered distribution of lysyl oxidase in the central nervous system of mutant SOD1 transgenic mouse model of amyotrophic lateral sclerosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Lysyl oxidase deficiency in lung and fibroblasts from mice with hereditary emphysema

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Decreased lysyl oxidase activity in the aneurysm-prone, mottled mouse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

copper ion binding

determination method

3 references

determination method

1 reference

14 February 2019

Transient expression of lysyl oxidase by liver myofibroblasts in murine schistosomiasis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28301&geneProductId=UniProtKB:P28301

determination method

extracellular space

determination method

3 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

determination method

2 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

extracellular matrix

determination method

5 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Lysyl oxidase binds transforming growth factor-beta and regulates its signaling via amine oxidase activity.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Muscle composition is regulated by a Lox-TGFβ feedback loop.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Extracellular-matrix gene expression during mouse submandibular gland development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

collagen-containing extracellular matrix

determination method

1 reference

14 February 2019

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

biological process

lung development

determination method

1 reference

14 February 2019

Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

aorta development

determination method

1 reference

14 February 2019

Global genetic analysis in mice unveils central role for cilia in congenital heart disease

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

heart development

determination method

1 reference

14 February 2019

Global genetic analysis in mice unveils central role for cilia in congenital heart disease

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

blood vessel development

determination method

1 reference

14 February 2019

Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28301&geneProductId=UniProtKB:P28301

determination method

response to hormone

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28301&geneProductId=UniProtKB:P28301

determination method

response to steroid hormone

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28301&geneProductId=UniProtKB:P28301

determination method

elastic fiber assembly

determination method

3 references

26 September 2017

Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28301&geneProductId=UniProtKB:P28301

determination method

26 September 2017

Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28301&geneProductId=UniProtKB:P28301

determination method

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28301&geneProductId=UniProtKB:P28301

determination method

blood vessel morphogenesis

determination method

1 reference

14 February 2019

Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

peptidyl-lysine oxidation

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

collagen fibril organization

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Lysyl oxidase activity contributes to collagen stabilization during liver fibrosis progression and limits spontaneous fibrosis reversal in mice.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

determination method

2 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

elastic fiber assembly

determination method

5 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Increased aortic stiffness and attenuated lysyl oxidase activity in obesity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

osteoblast differentiation

determination method

1 reference

14 February 2019

Lysyl oxidase (lox) gene deficiency affects osteoblastic phenotype.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

regulation of protein phosphorylation

determination method

1 reference

14 February 2019

Lysyl oxidase binds transforming growth factor-beta and regulates its signaling via amine oxidase activity.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

regulation of gene expression

determination method

1 reference

14 February 2019

Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

regulation of striated muscle tissue development

determination method

1 reference

14 February 2019

Muscle composition is regulated by a Lox-TGFβ feedback loop.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

regulation of transforming growth factor beta receptor signaling pathway

determination method

1 reference

14 February 2019

Muscle composition is regulated by a Lox-TGFβ feedback loop.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

bone mineralization

determination method

1 reference

14 February 2019

Lysyl oxidase (lox) gene deficiency affects osteoblastic phenotype.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

platelet-derived growth factor receptor-beta signaling pathway

determination method

ascending aorta development

determination method

1 reference

14 February 2019

Mechanical behavior and matrisome gene expression in the aneurysm-prone thoracic aorta of newborn lysyl oxidase knockout mice.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

descending aorta development

determination method

1 reference

14 February 2019

Mechanical behavior and matrisome gene expression in the aneurysm-prone thoracic aorta of newborn lysyl oxidase knockout mice.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

regulation of apoptotic process

determination method

1 reference

14 February 2019

Downregulation of Lysyl Oxidase Protects Retinal Endothelial Cells From High Glucose-Induced Apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

regulation of megakaryocyte differentiation

determination method

1 reference

14 February 2019

Control of megakaryocyte expansion and bone marrow fibrosis by lysyl oxidase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

muscle cell cellular homeostasis

determination method

1 reference

14 February 2019

Muscle composition is regulated by a Lox-TGFβ feedback loop.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

cell chemotaxis

determination method

connective tissue development

determination method

1 reference

14 February 2019

Muscle composition is regulated by a Lox-TGFβ feedback loop.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

cellular response to organic substance

determination method

1 reference

14 February 2019

Targeting lysyl oxidase reduces peritoneal fibrosis.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

DNA biosynthetic process

determination method

1 reference

14 February 2019

Lysyl oxidase (lox) gene deficiency affects osteoblastic phenotype.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

regulation of receptor binding

determination method

regulation of bone development

determination method

1 reference

14 February 2019

Control of megakaryocyte expansion and bone marrow fibrosis by lysyl oxidase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

cellular response to chemokine

determination method

1 reference

14 February 2019

Lysyl oxidase oxidizes cell membrane proteins and enhances the chemotactic response of vascular smooth muscle cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

regulation of platelet-derived growth factor receptor-beta signaling pathway

determination method

1 reference

14 February 2019

Control of megakaryocyte expansion and bone marrow fibrosis by lysyl oxidase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

platelet-derived growth factor receptor-beta signaling pathway

determination method

3 references

14 February 2019

Lysyl oxidase oxidizes cell membrane proteins and enhances the chemotactic response of vascular smooth muscle cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Lysyl oxidase oxidizes cell membrane proteins and enhances the chemotactic response of vascular smooth muscle cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

cell chemotaxis

determination method

3 references

14 February 2019

Lysyl oxidase oxidizes cell membrane proteins and enhances the chemotactic response of vascular smooth muscle cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Lysyl oxidase oxidizes cell membrane proteins and enhances the chemotactic response of vascular smooth muscle cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

regulation of receptor binding

determination method

3 references

14 February 2019

Lysyl oxidase oxidizes cell membrane proteins and enhances the chemotactic response of vascular smooth muscle cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Lysyl oxidase oxidizes cell membrane proteins and enhances the chemotactic response of vascular smooth muscle cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28301

determination method

Lysyl oxidase, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28301

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000025409

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000025409

ENSMUSP00000129247

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000129247

Sitelinks

Wikipedia(0 entries)

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Wikisource(0 entries)

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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