(Q14911833)

English

Lamin A

mammalian protein found in Mus musculus

Lmna
lamin C
prelamin-A/C
lamin-A/C
uniprot:P48678

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Lamin tail domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48678

Intermediate filament, rod domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Lamin tail domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Intermediate filament protein, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

structural molecule activity

determination method

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

protein binding

determination method

4 references

10 September 2018

Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

10 September 2018

Coupling of the nucleus and cytoplasm: role of the LINC complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

10 September 2018

Samp1 is a component of TAN lines and is required for nuclear movement

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

10 September 2018

Distinct changes in intranuclear lamin A/C organization during myoblast differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

identical protein binding

determination method

1 reference

10 September 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

protein phosphatase 1 binding

determination method

1 reference

10 September 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

determination method

1 reference

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

nuclear envelope

determination method

7 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

10 September 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

10 September 2018

Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

10 September 2018

Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

10 September 2018

A molecular mechanism underlying the neural-specific defect in torsinA mutant mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

determination method

1 reference

10 September 2018

cDNA cloning and functional characterization of a meiosis-specific protein (MNS1) with apparent nuclear association

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

intermediate filament

determination method

2 references

determination method

9 references

10 September 2018

Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

10 September 2018

Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

10 September 2018

Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

10 September 2018

The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

10 September 2018

Distinct changes in intranuclear lamin A/C organization during myoblast differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

10 September 2018

CDK4 is an essential insulin effector in adipocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

10 September 2018

Involvement of a novel preimplantation-specific gene encoding the high mobility group box protein Hmgpi in early embryonic development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

determination method

4 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

10 September 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

nuclear membrane

determination method

1 reference

10 September 2018

Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

determination method

1 reference

10 September 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

biological process

regulation of cell migration

determination method

1 reference

10 September 2018

Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

nucleus organization

determination method

1 reference

24 April 2018

Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

establishment or maintenance of microtubule cytoskeleton polarity

determination method

1 reference

10 September 2018

Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

negative regulation of release of cytochrome c from mitochondria

determination method

1 reference

10 September 2018

LMNA E82K mutation activates FAS and mitochondrial pathways of apoptosis in heart tissue specific transgenic mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

negative regulation of extrinsic apoptotic signaling pathway

determination method

1 reference

10 September 2018

LMNA E82K mutation activates FAS and mitochondrial pathways of apoptosis in heart tissue specific transgenic mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

regulation of protein localization to nucleus

determination method

1 reference

10 September 2018

Samp1 is a component of TAN lines and is required for nuclear movement

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

positive regulation of gene expression

determination method

1 reference

10 September 2018

Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

establishment of cell polarity

determination method

1 reference

10 September 2018

Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

ventricular cardiac muscle cell development

determination method

1 reference

10 September 2018

Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

negative regulation of mesenchymal cell proliferation

determination method

1 reference

10 September 2018

Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

regulation of telomere maintenance

determination method

1 reference

10 September 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

negative regulation of cardiac muscle hypertrophy in response to stress

determination method

1 reference

10 September 2018

Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

protein import into nucleus

determination method

1 reference

10 September 2018

Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

positive regulation of osteoblast differentiation

determination method

1 reference

10 September 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

negative regulation of adipose tissue development

determination method

1 reference

10 September 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

regulation of protein stability

determination method

1 reference

10 September 2018

Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

positive regulation of histone H3-K9 trimethylation

determination method

1 reference

10 September 2018

Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

determination method

Lamin tail domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48678

Intermediate filament protein, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48678

Intermediate filament, rod domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48678

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000029699

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000029699

ENSMUSP00000040265

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000040265

ENSMUSP00000113093

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000113093

ENSMUSP00000120784

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000120784

PDB structure ID

1 reference

UniProt protein ID

10 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q14911833&oldid=2023074121"