(Q14912180)

English

Angiopoietin 1

mammalian protein found in Mus musculus

uniprot:O08538
angiopoietin-1
Angpt1

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Fibrinogen-like, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O08538

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O08538

Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O08538

Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Fibrinogen, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

signaling receptor binding

determination method

1 reference

14 February 2019

Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

vascular endothelial growth factor receptor binding

determination method

1 reference

14 February 2019

Angiopoietins 3 and 4: diverging gene counterparts in mice and humans

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

plasma membrane

determination method

2 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

extracellular region

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

determination method

2 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

determination method

2 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

biological process

negative regulation of neuron apoptotic process

determination method

negative regulation of protein phosphorylation

determination method

1 reference

14 February 2019

Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

positive regulation of vascular endothelial growth factor receptor signaling pathway

determination method

1 reference

14 February 2019

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

cell differentiation

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

endoderm development

determination method

1 reference

14 February 2019

Angiopoietins 3 and 4: diverging gene counterparts in mice and humans

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

regulation of tumor necrosis factor production

determination method

1 reference

14 February 2019

Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

transmembrane receptor protein tyrosine kinase signaling pathway

determination method

1 reference

14 February 2019

Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

negative regulation of cytokine production involved in immune response

determination method

1 reference

14 February 2019

Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

in utero embryonic development

determination method

cardiac muscle tissue morphogenesis

determination method

1 reference

14 February 2019

Epicardial-myocardial signaling directing coronary vasculogenesis

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

endocardium morphogenesis

determination method

1 reference

14 February 2019

Epicardial-myocardial signaling directing coronary vasculogenesis

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

positive regulation of peptidyl-serine phosphorylation

determination method

1 reference

14 February 2019

An Ang1-Tie2-PI3K axis in neural progenitor cells initiates survival responses against oxygen and glucose deprivation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

determination method

1 reference

14 February 2019

Epicardial-myocardial signaling directing coronary vasculogenesis

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

multicellular organism development

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

positive regulation of endothelial cell migration

determination method

3 references

cell-substrate adhesion

determination method

1 reference

14 February 2019

Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

determination method

4 references

14 February 2019

Angiopoietin-1 mediates the proangiogenic activity of the bone morphogenic protein antagonist Drm

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

14 February 2019

Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

Tie signaling pathway

determination method

4 references

14 February 2019

Epicardial-myocardial signaling directing coronary vasculogenesis

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

regulation of macrophage migration inhibitory factor signaling pathway

determination method

1 reference

14 February 2019

Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

positive regulation of peptidyl-tyrosine phosphorylation

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

14 February 2019

Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

14 February 2019

An Ang1-Tie2-PI3K axis in neural progenitor cells initiates survival responses against oxygen and glucose deprivation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

branching involved in blood vessel morphogenesis

determination method

1 reference

14 February 2019

Epicardial-myocardial signaling directing coronary vasculogenesis

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

positive regulation of phosphatidylinositol 3-kinase signaling

determination method

1 reference

14 February 2019

An Ang1-Tie2-PI3K axis in neural progenitor cells initiates survival responses against oxygen and glucose deprivation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

regulation of protein binding

determination method

1 reference

14 February 2019

Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

vasculogenesis involved in coronary vascular morphogenesis

determination method

1 reference

14 February 2019

Epicardial-myocardial signaling directing coronary vasculogenesis

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

regulation of I-kappaB kinase/NF-kappaB signaling

determination method

1 reference

14 February 2019

Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

negative regulation of vascular permeability

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

14 February 2019

Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

14 February 2019

Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

negative regulation of protein import into nucleus

determination method

1 reference

14 February 2019

Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

positive regulation of cell adhesion

determination method

1 reference

14 February 2019

Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

determination method

1 reference

14 February 2019

Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

ovarian follicle development

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

protein homooligomerization

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08538

determination method

Fibrinogen, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O08538

Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O08538

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000022921

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000022921

Sitelinks

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Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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