(Q14914341)

SMAD-like domain superfamily

1 reference

Winged helix-like DNA-binding domain superfamily

1 reference

SMAD/FHA domain superfamily

1 reference

Interferon regulatory factors

1 reference

based on heuristic

inferred from protein domain or family

Interferon regulatory factor-3, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

DNA-binding transcription factor activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

protein homodimerization activity

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

14 February 2019

TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

14 February 2019

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

14 February 2019

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

DNA-binding transcription activator activity, RNA polymerase II-specific

4 references

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70671&geneProductId=UniProtKB:P70671

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70671&geneProductId=UniProtKB:P70671

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

identical protein binding

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

14 February 2019

Murine gammaherpesvirus 68 encoding open reading frame 11 targets TANK binding kinase 1 to negatively regulate the host type I interferon response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

14 February 2019

A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

14 February 2019

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

1 January 2018

The Type I Interferon-IRF7 Axis Mediates Transcriptional Expression of Usp25 Gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70671&geneProductId=UniProtKB:P70671

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

protein domain specific binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

identical protein binding

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

9 May 2019

A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

9 May 2019

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

9 May 2019

Murine gammaherpesvirus 68 encoding open reading frame 11 targets TANK binding kinase 1 to negatively regulate the host type I interferon response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

protein homodimerization activity

IPI

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

9 May 2019

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

9 May 2019

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

9 May 2019

TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

sequence-specific DNA binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70671&geneProductId=UniProtKB:P70671

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70671&geneProductId=UniProtKB:P70671

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70671&geneProductId=UniProtKB:P70671

24 April 2018

Characterization of a novel isoform of murine interferon regulatory factor 3

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70671&geneProductId=UniProtKB:P70671

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70671&geneProductId=UniProtKB:P70671

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70671&geneProductId=UniProtKB:P70671

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70671&geneProductId=UniProtKB:P70671

1 January 2018

Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70671&geneProductId=UniProtKB:P70671

1 January 2018

Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70671&geneProductId=UniProtKB:P70671

3 references

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

9 May 2019

Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

9 May 2019

Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

defense response to virus

IBA

biological process

4 references

9 May 2019

The Type I Interferon-IRF7 Axis Mediates Transcriptional Expression of Usp25 Gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

9 May 2019

Interferon Regulatory Factor IRF-7 Induces the Antiviral Alpha Interferon Response and Protects against Lethal West Nile Virus Infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

9 May 2019

The transcription factor IRF3 triggers "defensive suicide" necrosis in response to viral and bacterial pathogens

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

innate immune response

1 reference

9 May 2019

cellular response to lipopolysaccharide

1 reference

9 May 2019

Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

positive regulation of interferon-beta production

TAS

cellular response to dsRNA

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70671&geneProductId=UniProtKB:P70671

programmed necrotic cell death

1 reference

9 May 2019

The transcription factor IRF3 triggers "defensive suicide" necrosis in response to viral and bacterial pathogens

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

regulation of transcription, DNA-templated

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

transcription, DNA-templated

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70671&geneProductId=UniProtKB:P70671

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70671&geneProductId=UniProtKB:P70671

immune system process

1 reference

1 January 2018

positive regulation of interferon-alpha production

1 reference

9 May 2019

Interferon Regulatory Factor IRF-7 Induces the Antiviral Alpha Interferon Response and Protects against Lethal West Nile Virus Infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

positive regulation of type I interferon-mediated signaling pathway

1 reference

9 May 2019

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1

response to bacterium

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

transcription by RNA polymerase II

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70671&geneProductId=UniProtKB:P70671

negative regulation of transcription by RNA polymerase II

1 reference

24 April 2018

Characterization of a novel isoform of murine interferon regulatory factor 3

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70671&geneProductId=UniProtKB:P70671

negative regulation of defense response to virus by host

1 reference

24 April 2018

Characterization of a novel isoform of murine interferon regulatory factor 3

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70671&geneProductId=UniProtKB:P70671

negative regulation of transcription by RNA polymerase II

1 reference

7 November 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70671&geneProductId=UniProtKB:P70671

cellular response to exogenous dsRNA

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

regulation of gene expression

1 reference

9 May 2019

Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

regulation of inflammatory response

IGI

1 reference

9 May 2019

Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

positive regulation of transcription, DNA-templated

IGI

1 reference

9 May 2019

The Type I Interferon-IRF7 Axis Mediates Transcriptional Expression of Usp25 Gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

type I interferon signaling pathway

1 reference

9 May 2019

The Type I Interferon-IRF7 Axis Mediates Transcriptional Expression of Usp25 Gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

positive regulation of type I interferon production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

TRIF-dependent toll-like receptor signaling pathway

ISS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

positive regulation of transcription by RNA polymerase II

ISS

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70671

Interferon regulatory factor DNA-binding domain

has part(s)

1 reference

Interferon regulatory factor, conserved site

1 reference

Interferon regulatory factor-3

1 reference