(Q14914386)

http://www.ebi.ac.uk/interpro/protein/O35099

Sterile alpha motif/pointed domain superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35099

Domain of unknown function DUF4071, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

protein kinase activity

protein homodimerization activity

ISO

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

protein serine/threonine kinase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

5 references

8 April 2019

Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

8 April 2019

Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

8 April 2019

Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

8 April 2019

Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

8 April 2019

Identification of a novel antiapoptotic protein that antagonizes ASK1 and CAD activities

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

MAP kinase kinase kinase activity

IPI

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35099&geneProductId=UniProtKB:O35099

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35099&geneProductId=UniProtKB:O35099

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35099&geneProductId=UniProtKB:O35099

24 April 2018

Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35099&geneProductId=UniProtKB:O35099

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation

protein kinase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

IPI

magnesium ion binding

protein kinase activity

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

MAP kinase kinase kinase activity

IBA

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

8 April 2019

Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

IBA

cell component

endoplasmic reticulum

1 reference

8 April 2019

intrinsic apoptotic signaling pathway in response to oxidative stress

biological process

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35099&geneProductId=UniProtKB:O35099

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35099&geneProductId=UniProtKB:O35099

24 April 2018

Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35099&geneProductId=UniProtKB:O35099

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

immune system process

1 reference

8 April 2019

Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death

regulation of cell death

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

positive regulation of neuron death

IGI

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

8 April 2019

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

positive regulation of JNK cascade

1 reference

8 April 2019

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

response to endoplasmic reticulum stress

IMP

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

8 April 2019

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

cellular response to reactive nitrogen species

1 reference

8 April 2019

Signaling pathways from membrane lipid rafts to JNK1 activation in reactive nitrogen species-induced non-apoptotic cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

1 reference

8 April 2019

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

positive regulation of myoblast differentiation

1 reference

8 April 2019

TGF-β-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) interact with the promyogenic receptor Cdo to promote myogenic differentiation via activation of p38MAPK pathway

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

positive regulation of apoptotic process

IDA

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

8 April 2019

Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

1 reference

8 April 2019

TGF-β-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) interact with the promyogenic receptor Cdo to promote myogenic differentiation via activation of p38MAPK pathway

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

programmed necrotic cell death

IEP

1 reference

8 April 2019

Signaling pathways from membrane lipid rafts to JNK1 activation in reactive nitrogen species-induced non-apoptotic cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

IMP

innate immune response

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

cellular response to tumor necrosis factor

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

endothelial cell apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

intrinsic apoptotic signaling pathway in response to oxidative stress

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

8 April 2019

Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35099