Wikidata

(Q14914630)

English

T cell acute lymphocytic leukemia 1

mammalian protein found in Mus musculus

  • stem cell protein
  • Tal1
  • T-cell acute lymphocytic leukemia protein 1 homolog
In more languages

Statements

molecular function
protein binding
determination method
IPI
10 references
retrieved
14 February 2019
stated in
The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation
GOA
curator
UniProt
UniProt protein ID
P22091
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IPI
retrieved
14 February 2019
stated in
RFP represses transcriptional activation by bHLH transcription factors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IPI
retrieved
14 February 2019
stated in
More than blood, a novel gene required for mammalian postimplantation development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IPI
retrieved
14 February 2019
stated in
Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IPI
retrieved
14 February 2019
stated in
LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IPI
retrieved
14 February 2019
stated in
Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IPI
retrieved
14 February 2019
stated in
Eto2/MTG16 and MTGR1 are heteromeric corepressors of the TAL1/SCL transcription factor in murine erythroid progenitors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IPI
retrieved
14 February 2019
stated in
Eto2/MTG16 and MTGR1 are heteromeric corepressors of the TAL1/SCL transcription factor in murine erythroid progenitors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IPI
retrieved
14 February 2019
stated in
ETO2 coordinates cellular proliferation and differentiation during erythropoiesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IPI
retrieved
14 February 2019
stated in
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IPI
cell component
nucleus
determination method
IDA
IEA
ISO
6 references
retrieved
21 June 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091
determination method
ISO
retrieved
21 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P22091
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091
determination method
IEA
retrieved
21 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091
determination method
IEA
retrieved
21 June 2018
stated in
The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation
GOA
curator
UniProt
UniProt protein ID
P22091
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091
determination method
IDA
retrieved
21 June 2018
stated in
SCL and associated proteins distinguish active from repressive GATA transcription factor complexes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091
determination method
IDA
retrieved
21 June 2018
stated in
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091
determination method
IDA
nucleus
determination method
IBA
IDA
IEA
ISO
7 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P22091
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IEA
retrieved
14 February 2019
stated in
The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation
GOA
curator
UniProt
UniProt protein ID
P22091
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IDA
retrieved
14 February 2019
stated in
SCL and associated proteins distinguish active from repressive GATA transcription factor complexes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IDA
retrieved
14 February 2019
stated in
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IBA
biological process
embryonic hemopoiesis
determination method
IMP
5 references
retrieved
14 February 2019
stated in
Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival
GOA
curator
UniProt
UniProt protein ID
P22091
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IMP
retrieved
14 February 2019
stated in
Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IMP
retrieved
14 February 2019
stated in
Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IMP
retrieved
14 February 2019
stated in
Hematopoietic-specific genes are not induced during in vitro differentiation of scl-null embryonic stem cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IMP
retrieved
14 February 2019
stated in
Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IMP
positive regulation of transcription by RNA polymerase II
determination method
IGI
IEA
ISO
7 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
ISO
retrieved
14 February 2019
stated in
Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IGI
retrieved
14 February 2019
stated in
Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IGI
retrieved
14 February 2019
stated in
LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IGI
retrieved
14 February 2019
stated in
TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IGI
retrieved
14 February 2019
stated in
Eto2/MTG16 and MTGR1 are heteromeric corepressors of the TAL1/SCL transcription factor in murine erythroid progenitors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IGI
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IEA
erythrocyte differentiation
determination method
IDA
IEA
IMP
ISO
TAS
6 references
retrieved
14 February 2019
stated in
MTB, the murine homolog of condensin II subunit CAP-G2, represses transcription and promotes erythroid cell differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
TAS
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
ISO
retrieved
14 February 2019
stated in
Selective rescue of early haematopoietic progenitors in Scl(-/-) mice by expressing Scl under the control of a stem cell enhancer
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IMP
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IEA
retrieved
14 February 2019
stated in
Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IDA
retrieved
14 February 2019
stated in
Selective rescue of early haematopoietic progenitors in Scl(-/-) mice by expressing Scl under the control of a stem cell enhancer
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method
IDA

Identifiers

 
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