(Q14916252)

English

Paired box 3

mammalian protein found in Mus musculus

uniprot:P24610
paired box gene 3
Pax3
PAX3/FKHR fusion
paired box protein Pax-3

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Homeobox-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24610

Winged helix-like DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24610

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Paired domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Paired box protein 7, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

determination method

2 references

sequence-specific DNA binding

determination method

3 references

14 February 2019

Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

14 February 2019

Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

chromatin binding

determination method

1 reference

14 February 2019

Pax3 functions at a nodal point in melanocyte stem cell differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

protein binding

determination method

5 references

14 February 2019

Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

14 February 2019

Pax3 functions at a nodal point in melanocyte stem cell differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

14 February 2019

Transcriptional activity of Pax3 is co-activated by TAZ

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

14 February 2019

Interaction of the pRB-family proteins with factors containing paired-like homeodomains

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

14 February 2019

Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

determination method

DNA-binding transcription factor activity

determination method

1 reference

14 February 2019

Pax genes and their role in organogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

HMG box domain binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

transcription regulator complex

determination method

1 reference

14 February 2019

Pax genes and their role in organogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

biological process

regulation of transcription, DNA-templated

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

spinal cord association neuron differentiation

determination method

1 reference

14 February 2019

Pax3 and Pax7 are expressed in commissural neurons and restrict ventral neuronal identity in the spinal cord

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

cardiac muscle cell differentiation

determination method

1 reference

14 February 2019

Skeletal myosin light chain kinase regulates skeletal myogenesis by phosphorylation of MEF2C

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

14 February 2019

Pax3 functions at a nodal point in melanocyte stem cell differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

transcription, DNA-templated

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24610&geneProductId=UniProtKB:P24610

determination method

nervous system development

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

multicellular organism development

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

heart development

determination method

1 reference

14 February 2019

p57Kip2 expression is enhanced during mid-cardiac murine development and is restricted to trabecular myocardium

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

neural tube closure

determination method

1 reference

14 February 2019

New semidominant mutations that affect mouse development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

mammary gland specification

determination method

1 reference

14 February 2019

Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

neural crest cell migration

determination method

1 reference

14 February 2019

New semidominant mutations that affect mouse development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

neural tube development

determination method

1 reference

14 February 2019

Neurofibromin deficiency in mice causes exencephaly and is a modifier for Splotch neural tube defects

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

positive regulation of cell population proliferation

determination method

1 reference

14 February 2019

Decreased neural crest stem cell expansion is responsible for the conotruncal heart defects within the splotch (Sp(2H))/Pax3 mouse mutant

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

skeletal muscle organ development

determination method

1 reference

14 February 2019

Identification of mechanosensitive genes during skeletal development: alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

skeletal muscle cell differentiation

determination method

1 reference

14 February 2019

Skeletal myosin light chain kinase regulates skeletal myogenesis by phosphorylation of MEF2C

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

developmental pigmentation

determination method

1 reference

14 February 2019

Effects of G-protein mutations on skin color

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

neuron fate commitment

determination method

1 reference

14 February 2019

Pax3 and Pax7 are expressed in commissural neurons and restrict ventral neuronal identity in the spinal cord

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

cell population proliferation

determination method

1 reference

14 February 2019

Divergent functions of murine Pax3 and Pax7 in limb muscle development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

positive regulation of transcription, DNA-templated

determination method

1 reference

14 February 2019

Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

positive regulation of transcription by RNA polymerase II

determination method

3 references

14 February 2019

Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

14 February 2019

Pax3 functions at a nodal point in melanocyte stem cell differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

14 February 2019

Transcriptional activity of Pax3 is co-activated by TAZ

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24610

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000084320

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000084320

ENSMUSP00000004994

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000004994

Sitelinks

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