Wikidata

(Q15996558)

English

Aprataxin

mammalian protein found in Homo sapiens

  • APTX
  • aprataxin
  • forkhead-associated domain histidine triad-like protein
  • FHA-HIT
In more languages

Statements

molecular function
protein binding
determination method
IPI
10 references
retrieved
8 April 2019
stated in
Aprataxin, a novel protein that protects against genotoxic stress
GOA
curator
UniProt
UniProt protein ID
Q7Z2E3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3
determination method
IPI
retrieved
8 April 2019
stated in
Nucleolar localization of aprataxin is dependent on interaction with nucleolin and on active ribosomal DNA transcription
GOA
curator
UniProt
UniProt protein ID
Q7Z2E3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3
determination method
IPI
retrieved
8 April 2019
stated in
XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining
GOA
curator
UniProt
UniProt protein ID
Q7Z2E3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3
determination method
IPI
retrieved
8 April 2019
stated in
Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein
GOA
curator
UniProt
UniProt protein ID
Q7Z2E3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3
determination method
IPI
retrieved
8 April 2019
stated in
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3
determination method
IPI
retrieved
8 April 2019
stated in
The FHA domain of aprataxin interacts with the C-terminal region of XRCC1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3
determination method
IPI
retrieved
8 April 2019
stated in
Aprataxin, a novel protein that protects against genotoxic stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3
determination method
IPI
retrieved
8 April 2019
stated in
The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3
determination method
IPI
retrieved
8 April 2019
stated in
XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3
determination method
IPI
DNA 5'-adenosine monophosphate hydrolase activity
determination method
IEA
IDA
6 references
retrieved
27 February 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z2E3&geneProductId=UniProtKB:Q7Z2E3
determination method
IEA
retrieved
27 February 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z2E3&geneProductId=UniProtKB:Q7Z2E3
determination method
IEA
retrieved
27 February 2018
stated in
Actions of aprataxin in multiple DNA repair pathways
GOA
curator
UniProt
UniProt protein ID
Q7Z2E3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z2E3&geneProductId=UniProtKB:Q7Z2E3
determination method
IDA
retrieved
27 February 2018
stated in
The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates
GOA
curator
UniProt
UniProt protein ID
Q7Z2E3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z2E3&geneProductId=UniProtKB:Q7Z2E3
determination method
IDA
retrieved
27 February 2018
stated in
Aprataxin forms a discrete branch in the HIT (histidine triad) superfamily of proteins with both DNA/RNA binding and nucleotide hydrolase activities
GOA
curator
UniProt
UniProt protein ID
Q7Z2E3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z2E3&geneProductId=UniProtKB:Q7Z2E3
determination method
IDA
retrieved
27 February 2018
stated in
Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate ends
GOA
curator
UniProt
UniProt protein ID
Q7Z2E3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z2E3&geneProductId=UniProtKB:Q7Z2E3
determination method
IDA
DNA 5'-adenosine monophosphate hydrolase activity
determination method
IBA
IDA
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3
determination method
IEA
retrieved
8 April 2019
stated in
Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate ends
GOA
curator
UniProt
UniProt protein ID
Q7Z2E3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3
determination method
IDA
retrieved
8 April 2019
stated in
Aprataxin forms a discrete branch in the HIT (histidine triad) superfamily of proteins with both DNA/RNA binding and nucleotide hydrolase activities
GOA
curator
UniProt
UniProt protein ID
Q7Z2E3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3
determination method
IDA
retrieved
8 April 2019
stated in
Actions of aprataxin in multiple DNA repair pathways
GOA
curator
UniProt
UniProt protein ID
Q7Z2E3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3
determination method
IDA
retrieved
8 April 2019
stated in
The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates
GOA
curator
UniProt
UniProt protein ID
Q7Z2E3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3
determination method
IBA
cell component
biological process
Gene Atlas image
PBB GE APTX 218527 at fs.png
732 × 530; 11 KB
0 references

Identifiers

RefSeq protein ID
Ensembl protein ID
 
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