(Q24302150)

X-ray repair cross complementing 4

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positive regulation of ligase activity

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Non-homologous end joining factor 1

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Enhanced genome annotation using structural profiles in the program 3D-PSSM

Stephen P Jackson

3

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author name string

Peter Ahnesorg

series ordinal

1

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Philippa Smith

series ordinal

2

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language of work or name

English

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publication date

27 January 2006

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published in

Cell

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volume

124

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issue

2

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page(s)

301-13

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cites work

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https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

FUGUE: sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties

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7 January 2021

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

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https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly

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https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination

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https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

The mechanism of non-homologous end-joining: a synopsis of synapsis

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7 January 2021

The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Mechanism of DNA double-strand break repair by non-homologous end joining

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https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Tetramerization and DNA ligase IV interaction of the DNA double-strand break repair protein XRCC4 are mutually exclusive

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

A biochemically defined system for mammalian nonhomologous DNA end joining

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https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Partners and pathwaysrepairing a double-strand break.

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https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Absence of DNA ligase IV protein in XR-1 cells: evidence for stabilization by XRCC4.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Lif1p targets the DNA ligase Lig4p to sites of DNA double-strand breaks

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https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domains

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient

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https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

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https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

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https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Defining interactions between DNA-PK and ligase IV/XRCC4.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

The role of DNA breaks in genomic instability and tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Defying death after DNA damage.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

DNA double-strand breaks: signaling, repair and the cancer connection

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

MDC1 is required for the intra-S-phase DNA damage checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Molecular views of recombination proteins and their control

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Mechanism and regulation of human non-homologous DNA end-joining

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Crystal structure of an Xrcc4-DNA ligase IV complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

DNA double strand break repair and chromosomal translocation: lessons from animal models

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Nonhomologous end joining and V(D)J recombination require an additional factor

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

DNA ligase IV from HeLa cell nuclei

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

MDC1 regulates DNA-PK autophosphorylation in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

DNA ligase IV and XRCC4 form a stable mixed tetramer that functions synergistically with other repair factors in a cell-free end-joining system

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Ku stimulation of DNA ligase IV-dependent ligation requires inward movement along the DNA molecule

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Saccharomyces cerevisiae LIF1: a function involved in DNA double-strand break repair related to mammalian XRCC4.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Crystal structure of the Xrcc4 DNA repair protein and implications for end joining

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

The DNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Ku recruits the XRCC4-ligase IV complex to DNA ends

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

DNA damage-dependent nuclear dynamics of the Mre11 complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

V(D)J recombination: RAG proteins, repair factors, and regulation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

DNA ligase III as a candidate component of backup pathways of nonhomologous end joining

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Mechanisms of DNA double strand break repair and chromosome aberration formation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021

Homologous recombination: from model organisms to human disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.12.031

7 January 2021